小花五味子中具有独特骨架的新降三萜类化合物小花五味子内酯B和C的结构及抗HIV活性

Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha.

作者信息

Li Rong-Tao, Han Quan-Bin, Zheng Yong-Tang, Wang Rui-Rui, Yang Liu-Meng, Lu Yang, Sang Su-Qin, Zheng Qi-Tai, Zhao Qin-Shi, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, P. R. China.

出版信息

Chem Commun (Camb). 2005 Jun 21(23):2936-8. doi: 10.1039/b501932j.

DOI:10.1039/b501932j

PMID:15957031

Abstract

Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C, were isolated from Schisandra micrantha; micrandilactone C exhibited an EC50 value of 7.71 microg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of make it a promising lead for therapeutic development of a new generation of anti-HIV drug.

摘要

从小花五味子中分离出两种具有独特降环阿尔廷烷骨架的新型高氧化态三萜类化合物，小花五味子内酯B和C；小花五味子内酯C对HIV-1复制表现出7.71微克/毫升的半数有效浓度（选择指数>25.94），且细胞毒性极小，其强大的抗HIV-1活性和独特的结构特征使其成为新一代抗HIV药物治疗开发的一个有前景的先导物。