Centre for Fundamental and Advanced Technical Research, Romanian Academy-Timisoara Branch, Mihai Viteazul Str. 24, RO-300223 Timisoara, Romania.
Faculty of Physics, West University of Timisoara, Vasile Parvan Str. 1, RO-300222 Timisoara, Romania.
Molecules. 2019 Jul 9;24(13):2509. doi: 10.3390/molecules24132509.
The present study investigated the possibilities and feasibility of drug targeting for an arterial bifurcation lesion to influence the host healing response. A micrometer sized iron particle was used only to model the magnetic carrier in the experimental investigation (not intended for clinical use), to demonstrate the feasibility of the particle targeting at the lesion site and facilitate the new experimental investigations using coated superparamagnetic iron oxide nanoparticles. Magnetic fields were generated by a single permanent external magnet (ferrite magnet). Artery bifurcation exerts severe impacts on drug distribution, both in the main vessel and the branches, practically inducing an uneven drug concentration distribution in the bifurcation lesion area. There are permanently positioned magnets in the vicinity of the bifurcation near the diseased area. The generated magnetic field induced deviation of the injected ferromagnetic particles and were captured onto the vessel wall of the test section. To increase the particle accumulation in the targeted region and consequently avoid the polypharmacology (interaction of the injected drug particles with multiple target sites), it is critical to understand flow hemodynamics and the correlation between flow structure, magnetic field gradient, and spatial position.
本研究探讨了药物靶向治疗动脉分叉病变以影响宿主愈合反应的可能性和可行性。使用微米级的铁颗粒仅模拟实验研究中的磁性载体（不适用于临床用途），以证明颗粒在病变部位靶向的可行性，并促进使用涂层超顺磁氧化铁纳米颗粒的新实验研究。磁场由单个外部永磁体（铁氧体磁铁）产生。动脉分叉对药物分布有严重影响，无论是在主血管还是分支中，实际上都会导致分叉病变区域的药物浓度分布不均匀。在病变区域附近的分叉处附近有永久性定位磁铁。产生的磁场会导致注入的铁磁颗粒发生偏差，并被捕获到测试段的血管壁上。为了增加目标区域的颗粒积累，从而避免多药理学（注入药物颗粒与多个目标部位的相互作用），了解流体力学生和流结构、磁场梯度和空间位置之间的相关性至关重要。
