Moiseev Roman V, Morrison Peter W J, Steele Fraser, Khutoryanskiy Vitaliy V
Reading School of Pharmacy, University of Reading, Whiteknights, P.O. Box 224, Reading RG66AD, UK.
MC2 Therapeutics, James House, Emlyn Lane, Leatherhead KT22 7EP, UK.
Pharmaceutics. 2019 Jul 9;11(7):321. doi: 10.3390/pharmaceutics11070321.
There are more than 100 recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science. One of the ways to improve drug delivery to the eye is the use of penetration enhancers. These are defined as compounds capable of enhancing drug permeability across ocular membranes. This review paper provides an overview of anatomical and physiological features of the eye and discusses some common ophthalmological conditions and permeability of ocular membranes. The review also presents the analysis of literature on the use of penetration-enhancing compounds (cyclodextrins, chelating agents, crown ethers, bile acids and bile salts, cell-penetrating peptides, and other amphiphilic compounds) in ocular drug delivery, describing their properties and modes of action.
已确认的眼部疾病有100多种。这使得先进眼部制剂的研发成为药学领域的一个重要课题。改善药物眼部递送的方法之一是使用渗透促进剂。这些化合物被定义为能够增强药物跨眼膜渗透性的物质。这篇综述文章概述了眼睛的解剖学和生理学特征，并讨论了一些常见的眼科疾病以及眼膜的渗透性。该综述还分析了有关在眼部药物递送中使用渗透增强化合物（环糊精、螯合剂、冠醚、胆汁酸和胆盐、细胞穿透肽及其他两亲性化合物）的文献，描述了它们的特性和作用方式。
