Institute of Immunobiology and Human Genetics, Medical Faculty, University "Ss Cyril and Methodius", Skopje, Republic of North Macedonia.
Institute of Immunobiology and Human Genetics, Medical Faculty, University "Ss Cyril and Methodius", Skopje, Republic of North Macedonia.
Hum Immunol. 2019 Sep;80(9):629-630. doi: 10.1016/j.humimm.2019.07.277. Epub 2019 Jul 16.
The aim of this study was to determine the HLA allele and haplotype frequencies of the volunteer donors from the Macedonian Bone Marrow Donor Registry (MBMDR). We analyzed 1541 donors, from different nationalities and presented the HLA allele and haplotype frequencies for Macedonian, Albanian and Macedonian Muslims, most numerous nationalities in MBMDR. Difference between the three groups was observed for allele frequencies in HLA-C and HLA-DRB1 loci. The most common haplotype in Macedonian was HLA-A01-B08-C07-DRB103, while in Albanian and Macedonian Muslims HLA-A02-B18-C07-DRB111. This study confirmed the close relationship between the populations that live in the Balkan Peninsula.
本研究旨在确定来自马其顿骨髓捐赠者登记处（MBMDR）的志愿者供者的 HLA 等位基因和单倍型频率。我们分析了 1541 名来自不同民族的供者，并呈现了 MBMDR 中数量最多的马其顿人、阿尔巴尼亚人和马其顿穆斯林的 HLA 等位基因和单倍型频率。在 HLA-C 和 HLA-DRB1 基因座的等位基因频率方面，三个组之间存在差异。在马其顿人中最常见的单倍型是 HLA-A01-B08-C07-DRB103，而在阿尔巴尼亚人和马其顿穆斯林中则是 HLA-A02-B18-C07-DRB111。这项研究证实了居住在巴尔干半岛的人群之间的密切关系。
