Torres Leandro, da Silva Bouzas Luis Fernando, Almada Alexandre, de Sobrino Porto Luis Cristovão Moraes, Abdelhay Eliana
Registro Brasileiro de Doadores Voluntários de Medula Óssea - REDOME, Instituto Nacional do Câncer, INCA, Rio de Janeiro, Brazil; Rede Brasil de Imunogenética, Rio de Janeiro, Brazil.
Registro Brasileiro de Doadores Voluntários de Medula Óssea - REDOME, Instituto Nacional do Câncer, INCA, Rio de Janeiro, Brazil; Centro de Transplante de Medula Óssea, Instituto Nacional do Câncer, INCA, Rio de Janeiro, Brazil; Rede Brasil de Imunogenética, Rio de Janeiro, Brazil.
Hum Immunol. 2017 Oct;78(10):602-609. doi: 10.1016/j.humimm.2017.08.002. Epub 2017 Aug 10.
To improve assistance for patients awaiting a bone marrow transplant from an unrelated donor, it is important to genetically characterize the Brazilian volunteer bone marrow donors registry (REDOME). Our objective was to describe the antigenic groups and haplotype frequencies of HLA-A, HLA-B and HLA-DRB1 in the five regions of Brazil and by self-reported ethnicity groups using the REDOME data. Our study included 3,038,286 individuals. HLA antigenic groups and haplotype frequencies were estimated using an Expectation-Maximization (EM) algorithm. All described HLA-A*, HLA-B* and HLA-DRB1* groups were identified in this study. A02 (25.9%), B35 (11.8%) and DRB113 (13.4%) are the most frequent antigenic groups in REDOME, and the A01-B08-DRB103 haplotype is the most frequent in the registry. The antigenic group and haplotype frequency data obtained in this study could be helpful for national donor recruitment strategies across the country.
为改善对等待非亲属供体骨髓移植患者的援助，对巴西志愿骨髓供体登记处（REDOME）进行基因特征分析很重要。我们的目标是利用REDOME数据，描述巴西五个地区以及按自我报告的种族群体划分的HLA-A、HLA-B和HLA-DRB1的抗原组和单倍型频率。我们的研究纳入了3038286人。使用期望最大化（EM）算法估计HLA抗原组和单倍型频率。本研究中鉴定出了所有描述的HLA-A*、HLA-B和HLA-DRB1组。A02（25.9%）、B35（11.8%）和DRB113（13.4%）是REDOME中最常见的抗原组，A01-B08-DRB103单倍型是登记处中最常见的。本研究获得的抗原组和单倍型频率数据可能有助于全国范围内的供体招募策略。
