Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Cardiology Department of First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
J Cardiol. 2019 Dec;74(6):475-482. doi: 10.1016/j.jjcc.2019.05.018. Epub 2019 Jul 16.
Atrial fibrillation (AF) causes severe cardiac dysrhythmia among patients with cardiovascular diseases. AF increases the risk of stroke and heart failure and is a growing public health concern. AF is also associated with various disease conditions such as hypertension, coronary artery disease, aging, and diabetes mellitus. The mechanism underlying AF is not completely understood due to its complexity. However, experimental and clinical data have revealed that the prevalence of this disease is associated with atrial arrhythmogenic remodeling. Currently, there are no biomarkers that are available for the early diagnosis of AF. Several studies have proposed microRNAs (miRNAs) as useful biomarkers for the diagnosis of AF due to their stability and easy availability both in atrial tissue and circulating blood. miRNAs play an important role in the development of the heart. The dysregulation of miRNA expression is associated with cardiac remodeling. Genetic factors strongly contribute to the pathogenesis of AF. Recently, single nucleotide polymorphisms (SNPs) in various genes and miRNAs have been reported to be associated with AF. The aim of this review was to discuss the correlation between SNPs in miRNAs and AF, including those miRNAs that are commonly reported as potential biomarkers for AF.
心房颤动（AF）会导致心血管疾病患者出现严重的心律失常。AF 会增加中风和心力衰竭的风险，是一个日益受到关注的公共卫生问题。AF 还与各种疾病状况有关，如高血压、冠状动脉疾病、衰老和糖尿病。由于其复杂性，AF 的发病机制尚不完全清楚。然而，实验和临床数据表明，这种疾病的流行与心房心律失常性重构有关。目前，尚无可用于 AF 早期诊断的生物标志物。由于其在心房组织和循环血液中的稳定性和易于获得性，一些研究已经提出 microRNAs（miRNAs）作为有用的 AF 诊断生物标志物。miRNAs 在心脏发育中起着重要作用。miRNA 表达的失调与心脏重构有关。遗传因素对 AF 的发病机制有很大的影响。最近，已经报道了各种基因和 miRNAs 中的单核苷酸多态性（SNPs）与 AF 相关。本综述的目的是讨论 miRNAs 中的 SNPs 与 AF 之间的相关性，包括那些通常被报道为 AF 潜在生物标志物的 miRNAs。
