Health and Counseling Center, Osaka University, Toyonaka, Osaka, Japan.
J Investig Med. 2019 Oct;67(7):1082-1086. doi: 10.1136/jim-2018-000977. Epub 2019 Jul 19.
Stress is known as a risk factor for both mental and physical health problems. While stress is known as one of the major health problems in modern society, a biomarker of stress has not yet been well established. In the present study, we focused on the serum levels of α-Klotho (αKl) as a possible objective biomarker of stress. Subjects included apparently healthy individuals who underwent a health examination in the Osaka University Health and Counseling Center. Physical and biochemical parameters were obtained from all subjects. Information regarding the lifestyle of each individual was obtained via questionnaires. Among male subjects, serum levels of soluble αKl (sαKl) were significantly elevated in subjects who had poor stress management and unsatisfactory sleep, suggesting that stress management and sleeping conditions influenced the serum levels of sαKl. The total Kessler Screening Scale for Psychological Distress (K6) score was significantly increased in subjects who reported experiencing considerable stress, had poor stress management and unsatisfactory sleep. Since serum levels of sαKl showed the same tendency as the K6 score in terms of the relationship between stress management and sleeping conditions in male subjects, increased sαKl levels could be associated with considerable psychological stress in healthy men.
压力被认为是身心健康问题的一个风险因素。虽然压力是现代社会主要健康问题之一，但尚未很好地确定压力的生物标志物。在本研究中，我们专注于血清 α-Klotho（αKl）水平作为压力的一种可能的客观生物标志物。研究对象包括在大阪大学健康与咨询中心接受健康检查的明显健康个体。所有研究对象均获得了身体和生化参数。通过问卷获得了关于每个人生活方式的信息。在男性研究对象中，在那些压力管理不善和睡眠质量差的个体中，血清可溶性 αKl（sαKl）水平显著升高，表明压力管理和睡眠条件影响了 sαKl 的血清水平。在报告经历了相当大的压力、压力管理不善和睡眠质量差的研究对象中，总 Kessler 心理困扰筛查量表（K6）评分显著升高。由于血清 sαKl 水平与男性研究对象中压力管理和睡眠条件之间的 K6 评分具有相同的趋势，因此升高的 sαKl 水平可能与健康男性的相当大的心理压力有关。
