Health Care Division, Health and Counseling Center, Osaka University, Osaka, Japan.
Health Care Division, Health and Counseling Center, Osaka University, Osaka, Japan.
Clin Chim Acta. 2018 Jan;476:44-48. doi: 10.1016/j.cca.2017.11.007. Epub 2017 Nov 10.
Men and women react differently to some disease states, and women are reported to be more sensitive than men to the toxic effects of smoking. We examined the serum concentration of Klotho-related molecules, α-Klotho (αKl) and fibroblast growth factor (FGF)-21, and the influence of smoking on these molecules in both sexes.
Subjects included 90 men and 140 women in good health who underwent a health examination.
Among male subjects, serum concentrations of FGF-21, soluble sαKl, and inflammation-related cytokine interleukin (IL)-6 were significantly higher in smokers than in never-smokers. In females, serum concentrations of FGF-21 and IL-6 were significantly higher in smokers than in never-smokers; however, sαKl concentrations were slightly lower in smokers than in never-smokers. Serum concentrations of sαKl were correlated with smoking status and IL-6 only in male subjects, suggesting an anti-inflammatory effect of sαKl only in men. Serum concentrations of FGF-21 were correlated with the concentrations of total cholesterol, triglycerides, and HbA1c, which are important factors of metabolic disorders in females, suggesting that metabolic disorders in female smokers may be more serious than that in male smokers.
Klotho-related molecules showed a differential association and response to smoking between men and women.
男性和女性对某些疾病状态的反应不同，有报道称女性对吸烟的毒性作用比男性更为敏感。我们研究了血清 Klotho 相关分子（α-Klotho（αKl）和成纤维细胞生长因子（FGF）-21）的浓度，以及吸烟对这些分子在两性中的影响。
本研究纳入了 90 名男性和 140 名健康体检者。
在男性中，与从不吸烟者相比，吸烟者的血清 FGF-21、可溶性 sαKl 和炎症相关细胞因子白细胞介素（IL）-6 浓度显著更高。在女性中，与从不吸烟者相比，吸烟者的血清 FGF-21 和 IL-6 浓度更高，而 sαKl 浓度则略低。血清 sαKl 浓度仅与男性的吸烟状况和 IL-6 相关，表明 sαKl 仅在男性中具有抗炎作用。血清 FGF-21 浓度与总胆固醇、甘油三酯和 HbA1c 浓度相关，这些是女性代谢紊乱的重要因素，提示女性吸烟者的代谢紊乱可能比男性吸烟者更为严重。
Klotho 相关分子在男性和女性对吸烟的反应存在差异。
