Department of Family Medicine, College of Medicine, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia.
Department of Endocrinology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
J Clin Lab Anal. 2019 Nov;33(9):e22983. doi: 10.1002/jcla.22983. Epub 2019 Jul 19.
Subclinical hypothyroidism is defined as an increase in serum levels of Thyroid Stimulating Hormone (TSH) above the normal range, without alteration of total T4 concentrations that is reported to have association with various metabolic conditions. The study aimed to investigate any association between subclinical hypothyroidism and metabolic disorders in Al Kharj city.
This is a cross-sectional study that included review of patients' charts from prince Sattam bin Abdul-Aziz University, Al Kharj, Saudi Arabia, from August 1 to November 30, 2016. Data were analyzed with SPSS version 21. Descriptive statistics were obtained as frequencies. Pearson chi-square analysis was used to assess any differences between disease status and study variables. P-value < 0.05 was considered significant.
The mean age was 30.65 ± 13.3 with a female predominance. The average BMI was 29.5 ± 7.71; 46 (11.5%) had hypertension, 52 (46.8%) had diabetes, 173 (44%) had anemia, and 192 (56%) had vitamin D deficiency. Due to increased TSH levels, male gender had higher prevalence of subclinical hypothyroidism with P-value < 0.001 and 0.011, respectively.
Subclinical hypothyroidism is a significant topic worldwide whose prevalence is rising. In this study, we could not find any significant association between subclinical hypothyroidism and metabolic disorder. Further longitudinal studies with large sample size are needed to study this association.
亚临床甲状腺功能减退症定义为血清促甲状腺激素（TSH）水平升高超过正常范围，而总 T4 浓度不变，据报道与各种代谢状况有关。本研究旨在调查阿尔卡尔吉市亚临床甲状腺功能减退症与代谢紊乱之间的任何关联。
这是一项横断面研究，包括审查 2016 年 8 月 1 日至 11 月 30 日期间沙特阿拉伯阿尔卡尔吉王子萨塔姆·本·阿卜杜勒-阿齐兹大学的患者图表。使用 SPSS 版本 21 分析数据。获得描述性统计数据作为频率。采用 Pearson 卡方分析评估疾病状态与研究变量之间的任何差异。P 值<0.05 被认为具有统计学意义。
平均年龄为 30.65±13.3，女性居多。平均 BMI 为 29.5±7.71；46（11.5%）患有高血压，52（46.8%）患有糖尿病，173（44%）患有贫血，192（56%）患有维生素 D 缺乏症。由于 TSH 水平升高，男性亚临床甲状腺功能减退症的患病率更高，P 值分别为<0.001 和 0.011。
亚临床甲状腺功能减退症是一个全球性的重要课题，其患病率正在上升。在这项研究中，我们没有发现亚临床甲状腺功能减退症与代谢紊乱之间存在任何显著关联。需要进一步进行大规模的纵向研究来研究这种关联。
