Pant D C, Mowar A B, Chandra N
Professor,Department of Medicine, SRMSIMS, Bareilly, Uttar Pradesh.
Associate Professor, Department of Medicine, SRMSIMS, Bareilly, Uttar Pradesh.
J Assoc Physicians India. 2018 Jul;66(7):20-22.
Patients with diabetes & dyslipidaemia are at increased risk of developing coronary artery disease that many time manifests as life threatening ACS.
To study co-relation between HbA1c &total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) in diabetic patients with acute coronary syndrome and also their co-relationship with severity of ACS independently.
Blood samples of 51 known diabetic patients presented to emergency with ACS were sent for HbA1c & lipid profile estimation. All patients underwent coronary angiography. Obtained results were statistically analysed & co-related.
Patients were divided as having: 1. HDL <40, >40; 2. LDL <100, >100; 3. Total cholesterol <200, >200; 4. HbA1c 6.5-8.4, >8.4; 5. Single vessel disease (SVD) / multi vessel disease (MVD). Statistically significant direct co-relationship was found between HbA1c, LDL, Total cholesterol, ACS severity (SVD/MVD) & inverse co-relationship with HDL.
Severity & incidence of ACS in diabetic patients can be minimised by maintaining adequate glycaemic control & also by keeping circulating lipids under control.
糖尿病和血脂异常患者患冠状动脉疾病的风险增加，这种疾病常表现为危及生命的急性冠状动脉综合征（ACS）。
研究急性冠状动脉综合征糖尿病患者糖化血红蛋白（HbA1c）与总胆固醇、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）之间的相关性，以及它们与急性冠状动脉综合征严重程度之间的独立相关性。
对51例因急性冠状动脉综合征就诊于急诊科的已知糖尿病患者的血样进行糖化血红蛋白和血脂谱检测。所有患者均接受冠状动脉造影。对所得结果进行统计学分析并建立相关性。
患者被分为：1. HDL<40、>40；2. LDL<100、>100；3. 总胆固醇<200、>200；4. 糖化血红蛋白6.5 - 8.4、>8.4；5. 单支血管病变（SVD）/多支血管病变（MVD）。发现糖化血红蛋白、低密度脂蛋白、总胆固醇、急性冠状动脉综合征严重程度（SVD/MVD）之间存在统计学显著的直接相关性，与高密度脂蛋白存在负相关性。
通过维持适当的血糖控制以及控制循环血脂，可以将糖尿病患者急性冠状动脉综合征的严重程度和发病率降至最低。
