Division of Pharmaceutical, Social and Administrative Sciences, Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania 15282; Division of Pharmaceutical, Social and Administrative Sciences, Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, Pennsylvania 15282.
New Concept Product Initiative, Advantest Corporation, Sendai 989-3124, Japan.
J Pharm Sci. 2019 Nov;108(11):3478-3495. doi: 10.1016/j.xphs.2019.06.029. Epub 2019 Jul 17.
Refractive index is an important optical parameter that can be used to characterize the physicochemical properties of pharmaceutical solids. The complexity of most drugs and solid oral dosage systems introduces challenges for refractive index measurement methods. These challenges are highlighted, and different types of measurement methods are discussed in this review article. These measurements provide pharmaceutical scientists the opportunity to improve the drug-development process and enhance product quality. Pharmaceutical applications range from identification and quantification of drug crystallinity and polymorphism to mechanical strength assessment of tablets. This review article surveys the literature and evaluates the current and potential future characterization of pharmaceutical solids using refractive index measurements.
折射率是一个重要的光学参数，可用于描述药物固体的物理化学性质。大多数药物和固体制剂系统的复杂性给折射率测量方法带来了挑战。本文综述了这些挑战，并讨论了不同类型的测量方法。这些测量为药物科学家提供了改善药物开发过程和提高产品质量的机会。药物应用范围从鉴定和定量药物的结晶度和多晶型到评估片剂的机械强度。本文综述了文献，并评估了使用折射率测量对药物固体进行当前和潜在的未来特性描述。
