微小的变化，巨大的影响：mRNA 甲基化对多能性和发育中基因表达的影响。
Small changes, big implications: The impact of mA RNA methylation on gene expression in pluripotency and development.
机构信息
Program in Cell & Molecular Biology, and Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO 80525, United States of America.
Program in Cell & Molecular Biology, and Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO 80525, United States of America.
出版信息
Biochim Biophys Acta Gene Regul Mech. 2019 Sep;1862(9):194402. doi: 10.1016/j.bbagrm.2019.07.003. Epub 2019 Jul 17.
Abstract
In order to maintain a state of self-renewal, yet retain the ability to rapidly differentiate in response to external signals, pluripotent cells exert tight control over gene expression at many levels. Recent studies have suggested that N6-methyladenosine (mA) RNA methylation, one of the most abundant post-transcriptional modifications, is important for both pluripotency and differentiation. In this review, we summarize the current state of the mA field, with emphasis on the impact of writers, erasers and readers of mA on RNA metabolism and stem cell biology.
摘要
为了维持自我更新的状态，同时保持对外部信号快速分化的能力，多能细胞在多个层面上对基因表达进行严格控制。最近的研究表明，N6-甲基腺苷(m6A)RNA 甲基化是最丰富的转录后修饰之一，对多能性和分化都很重要。在这篇综述中，我们总结了 mA 领域的现状，重点介绍了 mA 的写入器、擦除器和读取器对 RNA 代谢和干细胞生物学的影响。
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