N6-甲基腺苷 RNA 修饰在多能性和重编程中的作用。
The N-Methyladenosine RNA modification in pluripotency and reprogramming.
机构信息
Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, SE-901 85 Umeå, Sweden; Department of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mount Sinai Center for RNA Biology and Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
出版信息
Curr Opin Genet Dev. 2017 Oct;46:77-82. doi: 10.1016/j.gde.2017.06.006. Epub 2017 Jul 3.
Chemical modifications of RNA provide a direct and rapid way to manipulate the existing transcriptome, allowing rapid responses to the changing environment further enriching the regulatory capacity of RNA. N-Methyladenosine (mA) has been identified as the most abundant internal modification of messenger RNA in eukaryotes, linking external stimuli to an intricate network of transcriptional, post-transcriptional and translational processes. MA modification affects a broad spectrum of cellular functions, including maintenance of the pluripotency of embryonic stem cells (ESCs) and the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). In this review, we summarize the most recent findings on mA modification with special focus on the different studies describing how mA is implicated in ESC self-renewal, cell fate specification and iPSC generation.
RNA 的化学修饰为操纵现有转录组提供了一种直接而快速的方法，使细胞能够快速响应不断变化的环境，从而进一步丰富了 RNA 的调控能力。N6-甲基腺苷（m6A）已被鉴定为真核生物中信使 RNA 最丰富的内部修饰，它将外部刺激与转录、转录后和翻译过程的复杂网络联系起来。mA 修饰影响广泛的细胞功能，包括维持胚胎干细胞（ESC）的多能性和体细胞重编程为诱导多能干细胞（iPSC）。在这篇综述中，我们总结了 mA 修饰的最新发现，特别关注了不同研究描述 mA 如何参与 ESC 自我更新、细胞命运特化和 iPSC 生成的研究。
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