Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
The Ronald O. Perelman Department of Dermatology, New York University, New York, New York.
J Am Acad Dermatol. 2020 Mar;82(3):628-633. doi: 10.1016/j.jaad.2019.07.036. Epub 2019 Jul 17.
Vitiligo is associated with medical conditions, primarily autoimmune disorders; however, only a few studies in the United States have investigated these associations.
Our purpose was to investigate the diseases associated with vitiligo in the New York, New York, population and evaluate if these associations differ by race/ethnicity and sex.
In this retrospective study, we analyzed data collected from the medical records of 1487 vitiligo patients seen at New York University during a 10-year period.
Vitiligo patients had a statistically significant higher prevalence of hypothyroidism, multiple sclerosis, rheumatoid arthritis, idiopathic thrombocytopenic purpura, seronegative arthritis, pernicious anemia, myasthenia gravis, inflammatory bowel disease, lymphoma, and systemic lupus erythematosus. Rates of comorbid autoimmune diseases varied by race and sex.
Medical charts did not consistently report race/ethnicity, type of vitiligo, and total body surface area affected. Information from nondermatology medical visits was also included.
This study revealed multiple new disease associations for vitiligo, including multiple sclerosis, idiopathic thrombocytopenic purpura, and lymphoma, as well as confirmed previously reported associations with other autoimmune diseases, the most common being hypothyroidism followed by rheumatoid arthritis. Associations did vary by race/ethnicity and sex.
白癜风与医学病症相关，主要为自身免疫性疾病；然而，美国仅有少数研究调查了这些关联。
我们旨在研究纽约市白癜风患者相关的疾病，并评估这些关联是否因种族/民族和性别而异。
在这项回顾性研究中，我们分析了在纽约大学就诊的 1487 名白癜风患者的医疗记录中收集的数据。
白癜风患者甲状腺功能减退症、多发性硬化症、类风湿性关节炎、特发性血小板减少性紫癜、血清阴性关节炎、恶性贫血、重症肌无力、炎症性肠病、淋巴瘤和系统性红斑狼疮的患病率存在统计学显著差异。合并自身免疫性疾病的比率因种族和性别而异。
病历并未始终报告种族/民族、白癜风类型和受影响的全身表面积。也包括了非皮肤科就诊的信息。
本研究揭示了白癜风的多种新的疾病关联，包括多发性硬化症、特发性血小板减少性紫癜和淋巴瘤，并证实了先前报告的与其他自身免疫性疾病的关联，最常见的是甲状腺功能减退症，其次是类风湿性关节炎。关联确实因种族/民族和性别而异。
