Department of Health Management, Jining No.1 People's Hospital, Jining Medical University, Jining 272000, Shandong, China.
Department of Medical Ultrasonics, Jining No.1 People's Hospital, Jining Medical University, Jining 272000, Shandong, China.
J Photochem Photobiol B. 2019 Aug;197:111547. doi: 10.1016/j.jphotobiol.2019.111547. Epub 2019 Jul 2.
In the present work, FeO nanoparticles with superparamagnetic properties were prepared and capped by using Chitosan. The synthesized NPs were studied by using transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectroscopy. Average particle size and surface charge of the synthesized NPs were characterized by using Malvern Zetasizer instrument. TEM images showed the morphology and size distribution of uncoated FeO NPs, exhibiting the uniform sized NPS with an average particle size of about 10 nm. Vibrating Scanning Magnetometry (VSM) experiments, showed the superparamagnetic nature of the prepared nanoparticles. FeO NPs showed ferromagnetic magnetization which is very sensitive towards the sample's nanostructure. The results of paramagnetic studies exhibited the substantial reduction in paramagnetic behavior after Chitosan coating but sufficient for responding in magnetic field. Further, the in-vitro ability of the Chitosan coated FeO NPs as contrast agents in efficient Ultra sound/Magnetic resonance (US/MR) imaging was investigated. These findings demonstrated that the Chitosan coated super para magnetic iron oxide nanoparticles (SPION) have reported significant contrast-enhanced imaging potential for dual-mode US/MR imaging. Hence, the prepared Chitosan coated SPION composites administration serve as potential guide in the diagnosis and treatment of cancers.
在本工作中，制备了具有超顺磁性的 FeO 纳米粒子，并通过壳聚糖进行了包覆。通过透射电子显微镜（TEM）和傅里叶变换红外（FTIR）光谱对合成的 NPs 进行了研究。通过 Malvern Zetasizer 仪器对合成 NPs 的平均粒径和表面电荷进行了表征。TEM 图像显示了未包覆的 FeO NPs 的形貌和粒径分布，表现出具有约 10nm 平均粒径的均匀尺寸的 NPs。振动扫描磁强计（VSM）实验表明，所制备的纳米粒子具有超顺磁性。FeO NPs 表现出铁磁性，这对样品的纳米结构非常敏感。顺磁研究的结果表明，壳聚糖包覆后顺磁行为显著降低，但足以对磁场做出响应。此外，还研究了壳聚糖包覆的 FeO NPs 作为高效超声/磁共振（US/MR）成像对比剂的体外能力。这些发现表明，壳聚糖包覆的超顺磁氧化铁纳米粒子（SPION）具有双模式 US/MR 成像的显著增强对比成像潜力。因此，制备的壳聚糖包覆的 SPION 复合材料的给药可作为癌症诊断和治疗的潜在指南。
