Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Neurotoxicology. 2019 Dec;75:9-13. doi: 10.1016/j.neuro.2019.06.009. Epub 2019 Jul 18.
Little data exists regarding the effect of chronic preoperative tramadol abuse on the clinical outcomes after surgery. Lumbar discectomy is a very common procedure that has a predictably high success rate for relief of radicular pain. In addition, the patient population presenting for this procedure has a high propensity for preoperative narcotic use.
The study aims to identify an association between preoperative tramadol abuse and clinical outcome after lumbar discectomy.
A descriptive controlled, non-randomized, clinical study.
Sixty patients underwent surgery for lumbar disc herniation. They were divided into two groups; control group and tramadol abuse group. Each group included 30 patients. They were operated between 2015 and 2016. Participants were evaluated pre-operatively and post-operatively every three months. Strict history taking regarding preoperative and postoperative pain medication utilization, operative time, hospital stay and complications were assessed. Pain was scored by a VAS for both lower limbs and back pain. The clinical outcomes were compared using the Prolo economic and functional rating scale.
In Tramadol abuse group, 12 (40%) continued to use tramadol after surgery. Tramadol abuse group showed worse clinical outcome parameters including worse VAS for low back pain and lower limb pain, worse Prolo economic, functional rating scale. In addition, tramadol abuse group showed significantly higher complications rate in the early post-operative and during the follow up period.
Tramadol abuse before lumbar discectomy was found to be associated with continued tramadol abuse after surgery and worse functional outcomes following surgery. Surgeons may want to counsel their patients about the potential for inferior clinical outcomes if narcotics were used before surgery.
关于慢性术前曲马多滥用对手术治疗后临床结果的影响,相关数据较少。腰椎间盘切除术是一种非常常见的手术,对神经根性疼痛的缓解具有可预测的高成功率。此外,接受该手术的患者群体术前有很高的使用麻醉药物的倾向。
本研究旨在确定术前曲马多滥用与腰椎间盘切除术的临床结果之间的关系。
描述性对照、非随机、临床研究。
60 名患者因腰椎间盘突出症接受手术。他们被分为两组:对照组和曲马多滥用组。每组包括 30 名患者。手术于 2015 年至 2016 年间进行。参与者在术前和术后每三个月进行评估。严格评估术前和术后疼痛药物使用、手术时间、住院时间和并发症的情况。采用视觉模拟评分法(VAS)对下肢和腰背疼痛进行评分。使用 Prolo 经济和功能评分量表比较临床结果。
在曲马多滥用组中,12 例(40%)患者术后继续使用曲马多。曲马多滥用组的临床结果参数较差,包括腰背疼痛的 VAS 评分较差、Prolo 经济、功能评分量表较差。此外,曲马多滥用组在术后早期和随访期间的并发症发生率明显较高。
腰椎间盘切除术前曲马多滥用与术后继续使用曲马多滥用以及术后功能结果较差有关。外科医生可能希望在术前使用麻醉药物之前向患者提供潜在的较差临床结果的咨询。