NHC Key Lab. of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China.
National Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Environ Int. 2019 Oct;131:105010. doi: 10.1016/j.envint.2019.105010. Epub 2019 Jul 18.
Neurotoxic effects of Polybrominated Diphenyl Ethers (PBDEs) at low levels have not been well studied in human population, and whether the associations can be explained by thyroid hormones (THs) remains unclear.
We examined the associations of prenatal PBDE exposures with THs in cord plasma and neurobehavior of children at 2 and 4 years among general population in China.
Participants were mother-child pairs in the Shanghai-Minhang Birth Cohort Study. Nine PBDE congeners and THs (thyroid stimulating hormone, total thyroxine, free thyroxine, total triiodothyronine, and free triiodothyronine) were determined in cord plasma. Child Behavior Checklist (CBCL/1.5-5) were completed by caregivers to assess children's neurobehavioral development at 2 and 4 years. In the final analyses, 199 and 307 mother-child pairs at 2 and 4 years were included to examine associations of PBDEs with CBCL scores using Pearson-scale-adjusted Poisson regressions, and 339 subjects were included in linear regression models to investigate the associations between PBDEs and THs.
BDE-47 had the highest detection rate of 83.82% with the median concentration of 0.19 ng/g lipid, followed by BDE-28, -99, -100 and -153 with detection rates nearly 50%. We found positive associations between prenatal PBDE concentrations and children's neurobehavior, including Somatic Complaints, Withdrawn, Sleep Problems and Internalizing Problems in girls, and Somatic Complaints and Attention Problems in boys. We also observed inverse associations of the sum of BDE-47, -28, -99, -100 and -153 with THs. However, by adding THs to the models examining associations between PBDEs and CBCL, the main results didn't measurably change.
This study adds new knowledge that prenatal PBDEs at low levels may be related to long-lasting behavioral abnormalities in children and reduced THs in cord plasma. However, the hypothesis that the neurotoxic impact of PBDEs may be explained by alterations in cord THs was not supported.
多溴二苯醚 (PBDEs) 在低水平下的神经毒性作用在人类群体中尚未得到充分研究，其与甲状腺激素 (THs) 之间的关联是否可以解释仍不清楚。
我们在中国的一般人群中，研究了产前 PBDE 暴露与脐带血浆中 THs 以及儿童 2 岁和 4 岁时神经行为之间的关系。
研究对象为上海闵行出生队列研究中的母婴对子。在脐带血浆中测定了 9 种 PBDE 同系物和 THs（促甲状腺激素、总甲状腺素、游离甲状腺素、总三碘甲状腺原氨酸和游离三碘甲状腺原氨酸）。在儿童 2 岁和 4 岁时，由照顾者完成儿童行为检查表 (CBCL/1.5-5) 以评估儿童的神经行为发育情况。在最终分析中，有 199 对母婴在 2 岁和 307 对母婴在 4 岁时被纳入研究，使用 Pearson 标度调整泊松回归分析 PBDE 与 CBCL 评分之间的关系，有 339 名受试者被纳入线性回归模型以研究 PBDEs 与 THs 之间的关系。
BDE-47 的检测率最高，为 83.82%，中位数浓度为 0.19ng/g 脂质，其次是 BDE-28、-99、-100 和 -153，检测率接近 50%。我们发现产前 PBDE 浓度与女孩的神经行为之间存在正相关，包括躯体抱怨、退缩、睡眠问题和内化问题，以及男孩的躯体抱怨和注意力问题。我们还观察到 BDE-47、-28、-99、-100 和 -153 的总和与 THs 呈负相关。然而，在检查 PBDEs 与 CBCL 之间关系的模型中加入 THs 后，主要结果并没有明显改变。
本研究增加了新的知识，即低水平的产前 PBDEs 可能与儿童长期的行为异常有关，并导致脐带血浆中 THs 减少。然而，PBDEs 的神经毒性影响可能通过改变脐带 THs 来解释的假设并未得到支持。
