Section of Epidemiology, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, P.O. Box 2099, 1014, Copenhagen K, Denmark.
National Centre for Register-Based Research, Aarhus University, Fuglesangs Allé 26, 8210, Aarhus V, Denmark.
Eur Child Adolesc Psychiatry. 2020 Mar;29(3):385-393. doi: 10.1007/s00787-019-01374-w. Epub 2019 Jul 20.
Increased frequency of psychosis-like experiences (PLEs) has been previously reported in children born to mothers with high general levels of alcohol intake during pregnancy. The aim of this study was to examine whether the risk of PLEs was likewise elevated in children prenatally exposed to binge drinking. Participants were 44,326 children and their mothers enrolled in the Danish National Birth Cohort from 1996-2002. Information on maternal binge drinking was collected twice in pregnancy by telephone interview and PLEs in the children were ascertained in a Web-based questionnaire at age 11. Analyses were carried out using weighted multinomial logistic regression models. Maternal binge drinking was relatively common among the participating women (27%). The adjusted relative risk ratio (RRR) for reporting one definite PLE symptom was 1.04 (95% confidence interval (CI) 0.95-1.13) and 1.06 (95% CI 0.95-1.20) for two or more symptoms in children exposed compared to unexposed to binge drinking during pregnancy. Furthermore, no association was found when addressing frequency and timing of binge drinking, nor for various levels of average alcohol consumption. When sub-dividing PLEs into specific types of experiences however, a slightly, although non-significant, increased risk was observed for one specific delusional idea, receiving messages from radio/TV, following prenatal exposure to binge drinking. Our results provide no evidence of an association between maternal binge drinking, nor average alcohol consumption in pregnancy, and overall occurrence of PLEs in the offspring. However, our results indicated that binge drinking might be related to a specific PLE.
先前有研究报道，母亲在怀孕期间大量饮酒会使所生孩子出现精神病样体验（PLE）的频率增加。本研究旨在探究胎儿是否也会因母亲孕期 binge drinking 而增加 PLE 的风险。研究对象为 1996 年至 2002 年期间参加丹麦国家出生队列的 44326 名儿童及其母亲。通过电话访谈在孕期两次收集母亲 binge drinking 的信息，并在儿童 11 岁时通过网络问卷确定 PLEs。使用加权多项逻辑回归模型进行分析。参与研究的女性 binge drinking 相对常见（27%）。与未暴露于孕期 binge drinking 的儿童相比，报告有一个明确的 PLE 症状的儿童的调整相对风险比（RRR）为 1.04（95%置信区间（CI）0.95-1.13），报告两个或更多症状的 RRR 为 1.06（95% CI 0.95-1.20）。此外，当考虑 binge drinking 的频率和时间以及各种水平的平均酒精摄入量时，并未发现关联。然而，当将 PLE 细分为特定类型的体验时，与孕期 binge drinking 暴露相关的一种特定妄想观念（收到来自广播/电视的信息）的风险略有增加，但无统计学意义。我们的结果并未提供证据表明母亲 binge drinking 或孕期平均酒精摄入量与后代总体 PLE 发生之间存在关联。然而，我们的结果表明 binge drinking 可能与特定的 PLE 有关。
