胎儿生长受限中母胎硫醇/二硫键平衡。
Maternal and fetal thiol/disulfide homeostasis in fetal growth restriction.
机构信息
Maternal Fetal Medicine, Etlik Zubeyde Hanim Kadin Hastaliklari Egitim ve Arastirma Hastanesi, Ankara, Turkey.
Obstetrics and Gynecology, Koc University Hospital, Topkapi, Turkey.
出版信息
J Matern Fetal Neonatal Med. 2021 May;34(10):1658-1665. doi: 10.1080/14767058.2019.1646239. Epub 2019 Aug 5.
PURPOSE
To evaluate thiol/disulfide homeostasis in both maternal and fetal compartment in the presence of fetal growth restriction (FGR).
MATERIALS AND METHODS
A prospective case-control study was carried out in women with FGR (: 40) or normally growing fetus (: 40). FGR was defined as estimated fetal weight below the 10th percentile for the gestational age. Maternal serum and fetal cord blood samples were collected from all participants and native thiol-disulfide exchanges were examined with automated method enabling the measurement of both sides of thiol-disulfide balance.
RESULTS
Native thiol, total thiol and disulfide amounts were decreased in the maternal serum and fetal cord blood of babies born to women with FGR ( < .05). The most sensitive marker was maternal native thiol (82.5, 95% confidence interval, 67.22-92.66%), while the maternal total thiol had highest specificity value (77.5, 95% confidence interval, 61.55-89.16%).
CONCLUSIONS
Maternal and fetal serum thiol/disulfide profiles may use prediction of FGR severity and its neonatal outcome.
目的
评估胎儿生长受限（FGR）时母体和胎儿腔室中硫醇/二硫键的动态平衡。
材料与方法
对 40 例 FGR 孕妇（病例组）和 40 例胎儿生长正常的孕妇（对照组）进行前瞻性病例对照研究。FGR 定义为估计胎儿体重低于相应胎龄第 10 百分位数。采集所有参与者的母体血清和胎儿脐静脉血样本，并采用自动化方法检测天然巯基-二硫键交换，以测量巯基-二硫键平衡的两侧。
结果
FGR 孕妇的母体血清和胎儿脐静脉血中的天然巯基、总巯基和二硫键含量均降低（<0.05）。最敏感的标志物是母体天然巯基（82.5，95%置信区间：67.22-92.66%），而母体总巯基具有最高的特异性值（77.5，95%置信区间：61.55-89.16%）。
结论
母体和胎儿血清巯基/二硫键谱可能用于预测 FGR 的严重程度及其新生儿结局。
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