Ozler Sibel, Oztas Efser, Guler Basak Gumus, Erel Ozcan, Caglar Ali Turhan, Ergin Merve, Danisman Nuri
Department of Perinatology in Selcuk University Faculty of Medicine, Konya, Turkey.
Department of Perinatology in Eskişehir City Hospital, Eskisehir, Turkey.
Fetal Pediatr Pathol. 2020 Apr;39(2):132-144. doi: 10.1080/15513815.2019.1644686. Epub 2019 Jul 30.
The main aim of this study was to investigate thiol/disulfide homeostasis associated with fetal growth restriction (FGR) and to evaluate whether alterations are predictive for adverse neonatal outcomes. 273 pregnant women (77 with FGR and 196 with normal fetal growth) were enrolled in this prospective case-control study. Native thiol and total thiol were decreased in FGR compared to the control group ( < .001; < .001). Decreased levels of maternal serum native and total thiol were significantly associated with adverse neonatal outcomes in FGR (OR: 0.983, 95% CI 0.976-0.991, < .001; OR: 0.983, 95% CI 0.976-0.991, < .001). Decreased maternal serum total thiol levels were the only significantly associated risk factor with adverse neonatal outcomes in FGR (OR: 0.981, 95% CI 0.963-1.000, = .046). The decrease in the antioxidants of thiol/disulfide mechanism may be related to the development of both FGR and adverse neonatal outcome in FGR.
本研究的主要目的是调查与胎儿生长受限（FGR）相关的硫醇/二硫键稳态，并评估这些改变是否可预测不良新生儿结局。273名孕妇（77名患有FGR，196名胎儿生长正常）参与了这项前瞻性病例对照研究。与对照组相比，FGR组的天然硫醇和总硫醇水平降低（<0.001；<0.001）。FGR组中，母体血清天然硫醇和总硫醇水平降低与不良新生儿结局显著相关（比值比：0.983，95%置信区间0.976 - 0.991，<0.001；比值比：0.983，95%置信区间0.976 - 0.991，<0.001）。母体血清总硫醇水平降低是FGR组中与不良新生儿结局唯一显著相关的危险因素（比值比：0.981，95%置信区间0.963 - 1.000，P = 0.046）。硫醇/二硫键机制抗氧化剂的减少可能与FGR的发生以及FGR中不良新生儿结局均有关。
