克罗恩病治疗靶点的演变。
Evolution of treatment targets in Crohn's disease.
机构信息
National Institute of Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK; Nottingham Digestive Diseases Centre, The University of Nottingham, Nottingham, UK.
Department of Medicine, Division of Gastroenterology, Western University, London, ON, Canada; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.
出版信息
Best Pract Res Clin Gastroenterol. 2019 Feb-Apr;38-39:101599. doi: 10.1016/j.bpg.2019.02.001. Epub 2019 Feb 16.
Crohn's disease is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract, associated with significantly morbidity due to both symptoms and complications that have a considerable detrimental impact on a patient's quality of life. An early treat to target approach with disease modifying agents has been shown to significantly improve long term outcomes, demonstrated by a number of therapeutic targets in a number of modalities. This review will outline the current treatment targets and measures of disease burden in Crohn's disease.
克罗恩病是一种慢性反复发作和缓解的胃肠道炎症性疾病，由于症状和并发症导致发病率显著升高，对患者的生活质量产生了相当大的不利影响。早期采用疾病修饰剂的靶向治疗方法已被证明可显著改善长期预后，这在多种治疗方式的多个治疗靶点中得到了证实。本综述将概述克罗恩病的当前治疗靶点和疾病负担的衡量标准。
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