AdventHealth East Orlando, 258 South Chickasaw Trail, Suite 203, Orlando, FL 32825, United States of America.
The Cardiac and Vascular Consultants, 1050 Old Camp Road, Suit 270, The Villages, FL 32162, USA.
Cardiovasc Revasc Med. 2020 Mar;21(3):404-408. doi: 10.1016/j.carrev.2019.05.026. Epub 2019 May 31.
Peripheral arterial disease (PAD) is a common atherosclerotic disease approximately affecting 8.5 million Americans above age 40 and is associated with significant functional impairment, morbidity and mortality from both cardiovascular and non-cardiovascular causes. PAD has increasing prevalence in females contrary to previous findings. Compared to men, women with PAD are more asymptomatic or have atypical symptoms. Women with PAD have increased quality of life impairment, increased risk of depression and increased cardiovascular mortality. The intent of this review is to provide an update on gender differences in PAD that can help in timely diagnosis and appropriate management through intensive cardiovascular risk factor modification, exercise program and guideline directed therapy to improve cardiovascular outcomes.
外周动脉疾病（PAD）是一种常见的动脉粥样硬化性疾病，大约影响 850 万 40 岁以上的美国人，与心血管和非心血管原因导致的显著功能障碍、发病率和死亡率有关。与之前的研究结果相反，PAD 在女性中的患病率呈上升趋势。与男性相比，患有 PAD 的女性症状更不明显或更不典型。患有 PAD 的女性生活质量受损更严重，患抑郁症的风险更高，心血管死亡率也更高。本综述的目的是提供关于 PAD 中性别差异的最新信息，这些信息可以通过强化心血管危险因素修正、运动方案和指南指导的治疗来改善心血管结局，从而有助于及时诊断和适当管理。
