基于环形超声换能器的小型化光声成像系统。
Ring ultrasound transducer based miniaturized photoacoustic imaging system.
作者信息
Dangi Ajay, Agrawal Sumit, Lieberknecht Jedidah, Zhang Jason, Kothapalli Sri-Rajasekhar
机构信息
Department of Biomedical Engineering, The Pennsylvania State University, State College, PA, USA.
Penn State Hershey Cancer Institute, The Pennsylvania State University, State College, PA, USA.
出版信息
Proc IEEE Sens. 2018 Oct;2018. doi: 10.1109/ICSENS.2018.8589908. Epub 2018 Dec 27.
In recent years photoacoustic microscopy systems have attracted significant attention from biomedical researchers due to its ability to provide label-free imaging of hemoglobin (vasculature), lipids, and melanin with high spatial and temporal resolutions even from deeper (> 1 mm) depths inside biological tissue. This work reports the development of a low-cost and miniaturized photoacoustic (PA) imaging device for microscopy applications. A ring ultrasound transducer with 2.5 mm outer diameter and 0.5 mm inner diameter is fabricated using a 150 μm thick PZT element as the piezoelectric layer. The ring ultrasound transducer is integrated with a pulsed laser diode with integrated optical fiber which is coaxially fed through the transducer. Raster scanning of the integrated device is used to obtain 3 dimensional images of a tissue-mimicking phantom.
近年来，光声显微镜系统因其能够在高空间和时间分辨率下对血红蛋白（血管系统）、脂质和黑色素进行无标记成像，甚至能对生物组织内部较深（>1mm）深度的区域成像，而受到生物医学研究人员的广泛关注。本文报道了一种用于显微镜应用的低成本、小型化光声（PA）成像设备的研制。采用厚度为150μm的PZT元件作为压电层，制作了外径2.5mm、内径0.5mm的环形超声换能器。该环形超声换能器与集成光纤的脉冲激光二极管集成在一起，光纤同轴穿过换能器。利用该集成设备的光栅扫描来获取仿组织体模的三维图像。
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