Department of Immunology, School of Medicine, Konkuk University, Chungju 27478, Korea.
Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba 272-8516, Japan.
Sci Adv. 2019 Jul 17;5(7):eaav8152. doi: 10.1126/sciadv.aav8152. eCollection 2019 Jul.
The function of regulatory immune cells in peripheral tissues is crucial to the onset and severity of various diseases. Interleukin-10 (IL-10)-producing regulatory B (IL-10 B) cells are known to suppress various inflammatory diseases. However, evidence for the mechanism by which IL-10 B cells are generated and maintained is still very limited. Here, we found that IL-10 B cells suppress the activation of IL-13-producing type 2 innate lymphoid cells (IL-13 ILC2s) in an IL-10-dependent manner in mice with oxazolone-induced severe contact hypersensitivity (CHS). Mast cell (MC) IL-5 was important for maintaining the population of IL-10 B cells in peripheral lymphoid tissues. Overall, these results uncover a previously unknown mechanism of MCs as a type of immunoregulatory cell and elucidate the cross-talk among MCs, IL-10 B cells, and IL-13 ILC2s in CHS.
调节性免疫细胞在周围组织中的功能对于各种疾病的发生和严重程度至关重要。已知产生白细胞介素-10（IL-10）的调节性 B（IL-10 B）细胞可抑制各种炎症性疾病。然而，对于 IL-10 B 细胞产生和维持的机制的证据仍然非常有限。在这里，我们发现 IL-10 B 细胞以 IL-10 依赖的方式抑制在 2,4-二硝基氟苯诱导的严重接触超敏反应（CHS）小鼠中产生白细胞介素-13 的 2 型先天淋巴样细胞（IL-13 ILC2）的活化。肥大细胞（MC）IL-5 对于维持外周淋巴组织中 IL-10 B 细胞的群体是重要的。总的来说，这些结果揭示了 MC 作为一种免疫调节细胞的先前未知的机制，并阐明了 MC、IL-10 B 细胞和 CHS 中的 IL-13 ILC2 之间的串扰。
