The Centenary Institute, Newtown, NSW 2042, Australia; Discipline of Dermatology, Sydney Medical School, University of Sydney, NSW 2006, Australia.
Malaghan Institute of Medical Research, Wellington, New Zealand.
Curr Opin Immunol. 2014 Dec;31:108-14. doi: 10.1016/j.coi.2014.10.008. Epub 2014 Oct 28.
Type 2 immune responses in the skin cause a variety of pathologies, including urticaria and atopic dermatitis. Traditionally, CD4(+) helper T cells have been implicated in the pathogenesis of these conditions. However, recently a new player, the group 2 innate lymphoid (ILC2) cell, has emerged as an important contributor to skin allergies. In this review, we summarize our current knowledge of the role ILC2 cells play in the physiology and pathology of mouse and human skin.
2 型免疫应答在皮肤中引起多种病理，包括荨麻疹和特应性皮炎。传统上，CD4(+)辅助 T 细胞被认为与这些疾病的发病机制有关。然而，最近一种新的细胞，即 2 型先天淋巴细胞（ILC2），已成为皮肤过敏的重要贡献者。在这篇综述中，我们总结了我们目前对 ILC2 细胞在小鼠和人类皮肤生理学和病理学中的作用的认识。
