Kim Hyuk Soon, Jang Jong-Hwa, Lee Min Bum, Jung In Duk, Kim Young Mi, Park Yeong-Min, Choi Wahn Soo
Department of Immunology, School of medicine, Konkuk University, Chungju 27478, Korea.
Department of Dental Hygiene, Hanseo University, Seosan 31962, Korea.
BMB Rep. 2016 May;49(5):293-6. doi: 10.5483/bmbrep.2016.49.5.023.
The immunoregulatory cytokine Interleukin 10 (IL-10) protein is produced by various cells during the course of inflammatory disorders. Mainly, it downregulates pro-inflammatory cytokines, antigen presentation, and helper T cell activation. In this study, we show that the ratio of IL-10-producing cells was significantly increased in lineage negative (i.e., not T, B, or leukocyte cell lineages) cells than in lineage positive cells in lymphoid and peripheral tissues. We further observed that IL-10-producing innate lymphoid cells (ILCs), here called firstly ILC10, were increased in number in oxazolone-induced contact hypersensitivity (CHS) mice. In detail, IL-10-producing lineage negative cells were elevated in the axillary, inguinal lymph node, and ear tissues of CHS mice. Notably, the cells expressed classical ILC marker proteins such as CD45, CD127, and Sca-1. Altogether, our findings suggest for the first time that ILC10s are present in various physiological settings and could be involved in numerous immune responses as regulatory cells. [BMB Reports 2016; 49(5): 293-296].
免疫调节细胞因子白细胞介素10（IL-10）蛋白是在炎症性疾病过程中由多种细胞产生的。主要是，它下调促炎细胞因子、抗原呈递和辅助性T细胞活化。在本研究中，我们发现，在淋巴组织和外周组织中，产生IL-10的细胞在谱系阴性（即非T、B或白细胞谱系）细胞中的比例显著高于谱系阳性细胞。我们进一步观察到，在恶唑酮诱导的接触性超敏反应（CHS）小鼠中，产生IL-10的固有淋巴细胞（ILC），这里首次称为ILC10，数量增加。具体而言，在CHS小鼠的腋窝、腹股沟淋巴结和耳部组织中，产生IL-10的谱系阴性细胞增多。值得注意的是，这些细胞表达经典的ILC标记蛋白，如CD45、CD127和Sca-1。总之，我们的研究结果首次表明，ILC10存在于各种生理环境中，并可能作为调节细胞参与多种免疫反应。[《BMB报告》2016年；49(5): 293 - 296]
