Department of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Rome, Italy.
Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
J Periodontol. 2019 Dec;90(12):1374-1382. doi: 10.1002/JPER.19-0077. Epub 2019 Aug 3.
Over the years, only few authors have studied the association of systemic conditions with peri-implantitis. The aim of this study is to detect frequency and severity of peri-implant diseases among an Italian population of patients affected by metabolic syndrome (MetS).
In this cross-sectional study, patients with at least one dental implant with >5 years of functional loading were screened to evaluate metabolic, periodontal, and peri-implant status. MetS diagnosis was established in accordance with the National Cholesterol Education Program (NCEP) ATP III criteria, while case definitions of the 2017 World Workshop were adopted for peri-implant diseases. For each implant, probing depths, mucosal redness, bleeding on probing, suppuration, plaque index, and marginal bone loss were recorded. Multinomial logistic regression analyzed the relationship between sex, diagnosis of MetS, presence of periodontitis, smoking, type of prosthesis, and location of implants and peri-implant mucositis and peri-implantitis.
A total of 183 patients were enrolled: in MetS subjects, peri-implantitis was detected in 36.9% (n = 31) of implants, and mucositis in 60.7% (n = 51), with an OR of 10.01(P = 0.005) for mucositis and OR 15.26 (P = 0.001) for peri-implantitis, compared with subjects without MetS, where 26.3% of implants showed peri-implantitis and 55.5% mucositis. No differences were found for smoking, implant location, sex, and type of prosthetic rehabilitation. Patients with periodontitis showed a higher association with peri-implant mucositis (OR = 4.33) and peri-implantitis (OR = 9.00).
Based on the results of this study, patients affected by MetS showed a greater prevalence of peri-implant diseases, but further studies are needed to confirm the possibility of this new possible risk indicator.
多年来，只有少数作者研究了全身状况与种植体周围炎的关系。本研究旨在检测意大利代谢综合征（MetS）患者群体中种植体周围疾病的频率和严重程度。
在这项横断面研究中，筛选了至少有一颗已使用超过 5 年的功能性负载的牙种植体的患者，以评估代谢、牙周和种植体周围状况。MetS 的诊断是根据国家胆固醇教育计划（NCEP）ATP III 标准确定的，而种植体周围疾病的 2017 年世界工作坊的病例定义被采用。对每个种植体，记录探诊深度、黏膜红肿、探诊出血、溢脓、菌斑指数和边缘骨丧失。多项逻辑回归分析了性别、MetS 诊断、牙周炎、吸烟、义齿类型和种植体位置与种植体周围黏膜炎和种植体周围炎之间的关系。
共纳入 183 名患者：在 MetS 患者中，36.9%（n=31）的种植体发生种植体周围炎，60.7%（n=51）的种植体发生黏膜炎，与无 MetS 的患者相比，黏膜炎的 OR 为 10.01（P=0.005），种植体周围炎的 OR 为 15.26（P=0.001）。吸烟、种植体位置、性别和义齿修复类型无差异。患有牙周炎的患者与种植体周围黏膜炎（OR=4.33）和种植体周围炎（OR=9.00）的相关性更高。
根据本研究的结果，患有 MetS 的患者发生种植体周围疾病的患病率更高，但需要进一步的研究来确认这种新的可能风险指标的可能性。
