种植牙治疗患者唾液中钛、镍、钒和砷的水平：一项病例对照研究。
Salivary Levels of Titanium, Nickel, Vanadium, and Arsenic in Patients Treated with Dental Implants: A Case-Control Study.
作者信息
Papi Piero, Raco Andrea, Pranno Nicola, Di Murro Bianca, Passarelli Pier Carmine, D'Addona Antonio, Pompa Giorgio, Barbieri Maurizio
机构信息
Department of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
Division of Oral Surgery and Implantology, Department of Head and Neck, Oral Surgery, and Implantology Unit, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
出版信息
J Clin Med. 2020 Apr 27;9(5):1264. doi: 10.3390/jcm9051264.
BACKGROUND
Recent articles have hypothesized a possible correlation between dental implants dissolution products and peri-implantitis. The null hypothesis tested in this case-control study was that there would be no differences in salivary concentrations of titanium (Ti), vanadium (V), nickel (Ni) and arsenic (As) ions among patients with dental implants, healthy (Group A) or affected by peri-implantitis (Group B), compared to subjects without implants and/or metallic prosthetic restorations (Group C).
METHODS
Inductively coupled plasma mass spectrometry was used to analyze saliva samples. One-way repeated-measure analysis of variance (ANOVA) was used to identify statistically significant differences in the salivary level of Ti, V, Ni and As between the three groups.
RESULTS
A total of 100 patients were enrolled in the study (42 males and 58 females), distributed in three groups: 50 patients in Group C, 26 patients in Group B and 24 patients Group B. In our study, concentrations of metallic ions were higher in Group A and B, compared to the control group, with the exception of vanadium. However, there were no statistically significant differences ( > 0.05) for metallic ions concentrations between Group A and Group B.
CONCLUSIONS
Based on our results, there are no differences in titanium or other metals concentrations in saliva of patients with healthy or diseased implants.
背景
近期的文章推测牙种植体溶解产物与种植体周围炎之间可能存在关联。在这项病例对照研究中所检验的零假设是，与无种植体和/或金属修复体的受试者（C组）相比，有牙种植体的健康患者（A组）或患有种植体周围炎的患者（B组）唾液中钛（Ti）、钒（V）、镍（Ni）和砷（As）离子的浓度没有差异。
方法
采用电感耦合等离子体质谱法分析唾液样本。使用单向重复测量方差分析（ANOVA）来确定三组之间唾液中Ti、V、Ni和As水平的统计学显著差异。
结果
共有100名患者纳入研究（42名男性和58名女性），分为三组：C组50名患者，B组26名患者，A组24名患者。在我们的研究中，与对照组相比，A组和B组中金属离子的浓度较高，但钒除外。然而，A组和B组之间金属离子浓度没有统计学显著差异（>0.05）。
结论
根据我们的结果，健康或患病种植体患者唾液中的钛或其他金属浓度没有差异。
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