1Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
2Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Tissue Eng Part C Methods. 2019 Aug;25(8):472-478. doi: 10.1089/ten.TEC.2019.0133.
Vascular tissue engineering (VTE) is a rapidly expanding field, with numerous approaches being explored both in preclinical and clinical settings. A pivotal factor in the development of VTE techniques is patient safety, notably with respect to the mechanical properties of the vessels. Of the mechanical properties, the bursting strength, representing the ability of a vessel to withstand the forces exerted on it by blood pressure, is the most important. The burst pressure is commonly assessed using one of three methods proposed by the ISO 7198. In this study, we evaluate the three burst pressure assessment methods exactly as they are presently in the field of VTE. We show that the indirect assessment methods, as they are presently used, provide inconsistent and therefore unreliable estimates of the true yield stress of a vessel.
血管组织工程（VTE）是一个快速发展的领域，在临床前和临床环境中都有许多方法正在被探索。VTE 技术发展的一个关键因素是患者安全，特别是在血管的机械性能方面。在机械性能中，爆裂强度代表了血管承受血压施加的力的能力，是最重要的。爆裂压力通常使用 ISO 7198 提出的三种方法之一进行评估。在这项研究中，我们如实地评估了三种爆裂压力评估方法在 VTE 领域的应用。我们表明，目前使用的间接评估方法提供了不一致的，因此也是不可靠的血管真实屈服应力的估计。
