Natural Products Chemistry Research Group, Organic Chemistry Division, Faculty of Science and Technology, Department of Chemistry, Universitas Airlangga, Surabaya, Indonesia.
Nat Prod Res. 2021 Apr;35(8):1256-1261. doi: 10.1080/14786419.2019.1644634. Epub 2019 Jul 22.
Meliquercifolins A (), and B (), two new coumarins are bearing an acetophenone derivative were isolated from the leaves of along with three known compounds, melicodenines E (), F () and I (). Structures of two new compounds were identified based on spectroscopic analyses (UV, HR-ESI-MS, 1 D and 2 D NMR). Cytotoxic activities of compounds ( towards three human cancer cells (HeLa, MCF-7, P-388), compounds , and showed very potent activity against Hela cells with IC values 2.6; 0.8; 1.1 μM, respectively.
从 中分离到两个新的香豆素类化合物，即 meliquercifolins A()和 B()，它们都含有一个苯乙酮衍生物，此外还分离到了 3 个已知化合物，即 melicodenines E()、F()和 I()。根据光谱分析（UV、HR-ESI-MS、1D 和 2D NMR）确定了两个新化合物的结构。化合物（对三种人癌细胞（HeLa、MCF-7、P-388）的细胞毒性活性表明，化合物 、和 对 Hela 细胞具有很强的活性，IC 值分别为 2.6、0.8 和 1.1 μM。
