New Acetophenones and Chromenes from the Leaves of A. Gray.

The dichloromethane extract from leaves of (Rutaceae), endemic to the Hawaiian island of Kaua'i, yielded four new and three previously known acetophenones and 2-chromenes, all found for the first time in . The structures of the new compounds obtained from the dichloromethane extract after purification by chromatographic methods were unambiguously elucidated by spectroscopic analyses including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration was determined by modified Mosher's method. Compounds , and the mixture of and exhibited moderate cytotoxic activities against the human ovarian cancer cell line A2780 with IC values of 30.0 and 75.7 µM for and , respectively, in a nuclear shrinkage cytotoxicity assay.