Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Molecules. 2021 Jan 28;26(3):688. doi: 10.3390/molecules26030688.
The dichloromethane extract from leaves of (Rutaceae), endemic to the Hawaiian island of Kaua'i, yielded four new and three previously known acetophenones and 2-chromenes, all found for the first time in . The structures of the new compounds obtained from the dichloromethane extract after purification by chromatographic methods were unambiguously elucidated by spectroscopic analyses including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration was determined by modified Mosher's method. Compounds , and the mixture of and exhibited moderate cytotoxic activities against the human ovarian cancer cell line A2780 with IC values of 30.0 and 75.7 µM for and , respectively, in a nuclear shrinkage cytotoxicity assay.
（芸香科）叶子的二氯甲烷提取物，仅分布于夏威夷考艾岛，分离得到了四个新的和三个以前已知的苯乙酮和 2-色烯，它们均为首次在 中发现。通过色谱方法对二氯甲烷提取物进行纯化后得到的新化合物的结构，通过包括 1D/2D NMR 光谱和 HRESIMS 的光谱分析得到了明确的阐明。通过改进的 Mosher 法确定了绝对构型。化合物 、 和 的混合物在核皱缩细胞毒性测定中对人卵巢癌细胞系 A2780 表现出中等的细胞毒性活性，IC 值分别为 30.0 和 75.7 μM。
