Laboratory of Pharmacognosy and Natural Products Chemistry, School of Pharmacy, University of Athens , Panepistimioupoli Zografou, 15771 Athens, Greece.
J Nat Prod. 2012 Jul 27;75(7):1270-6. doi: 10.1021/np201007a. Epub 2012 Jun 18.
Three new acetophenone dimers or Acronychia-type acetophenones, acropyrone (1), acropyranol A (2), and acropyranol B (3), were isolated from the trunk bark of Acronychia pedunculata and structurally characterized, together with four known acetophenone dimers, acrovestone (4), acrovestenol (5), acrofolione A (6), and acrofolione B (7), the acetophenone monomer acronyline (8), and four furoquinoline alkaloids. The chemical structures of the new isolated compounds were elucidated unambiguously by spectroscopic data analysis. The cytotoxic activities of the isolated acetophenone dimers were evaluated against the DU145 prostate and A2058 melanoma human cancer cell lines as well as the NHDF normal cell line. Acrovestone (4) and acrovestenol (5) exhibited substantial cytotoxicity, with IC(50) values of 0.38 and 2.8 μM against A2058 melanoma cells as well as 0.93 and 2.7 μM against DU145 prostate cancer cells, respectively.
从 Acronychia pedunculata 的树干皮中分离得到了三个新的苯乙酮二聚体或 Acronychia 型苯乙酮，分别为 acropyrone（1）、acropyranol A（2）和 acropyranol B（3），并对其结构进行了表征。此外，还分离得到了四个已知的苯乙酮二聚体，分别为 acrovestone（4）、acrovestenol（5）、acrofolione A（6）和 acrofolione B（7），一个苯乙酮单体 acronyline（8）以及四个呋喃喹啉生物碱。通过光谱数据分析，明确了新分离化合物的化学结构。对分离得到的苯乙酮二聚体进行了细胞毒性评价，结果显示 acrovestone（4）和 acrovestenol（5）对 A2058 黑色素瘤和 DU145 前列腺癌细胞系以及 NHDF 正常细胞系均具有显著的细胞毒性，其对 A2058 黑色素瘤细胞的 IC50 值分别为 0.38 和 2.8 μM，对 DU145 前列腺癌细胞的 IC50 值分别为 0.93 和 2.7 μM。
