大盖球孢菌：化学成分、抗菌活性及 7,7'-双二氢白鲜交酯的全 NMR 归属
Phialomyces macrosporus: Chemical Constituents, Antimicrobial Activity and Complete NMR Assignments for the 7,7'-Biphyscion.
机构信息
Departamento de Química Orgânica, Instituto de Química, Universidade Federal da Bahia, Rua Barão de Jeremoabo, 147 - Ondina, Salvador -, BA 40170-115, Brazil.
Laboratório Multiusuário de Caracterização e Análise, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Cidade Universitária, SN - Castelo Branco, João Pessoa -, PB 58051-900, Brazil.
出版信息
Chem Biodivers. 2019 Sep;16(9):e1900353. doi: 10.1002/cbdv.201900353. Epub 2019 Aug 20.
Five known secondary metabolites, chrysophanol (1), 7,7'-biphyscion (2), secalonic acid D (3), mannitol (4) and trehalose (5) were isolated for the first time from the extracts of the fungus Phialomyces macrosporus. Their structures were elucidated by NMR methods (1D and 2D NMR analysis), optical activity and ESI-MS. Complete H and C assignments were performed for compound 2. The antimicrobial activity was evaluated by serial microdilution assay for compounds 2 and 3 and results showed that compound 3 exhibited a significant growth inhibition at concentrations of 15.6 mg/ml (S. aureus and S. choleraesius) and 0.97 mg/mL (B. subtilis), comparable to the positive control.
从真菌大孢毛霉的提取物中分离到 5 种已知的次生代谢产物：大黄酚（1）、7,7′-双大孢菌素（2）、secalonic acid D（3）、甘露醇（4）和海藻糖（5）。通过 NMR 方法（1D 和 2D NMR 分析）、旋光和 ESI-MS 确定了它们的结构。完成了化合物 2 的完全 ¹H 和 ¹³C 分配。采用连续微量稀释法对化合物 2 和 3 进行了抗菌活性评价，结果表明化合物 3 在 15.6mg/ml（金黄色葡萄球菌和肠炎沙门氏菌）和 0.97mg/ml（枯草芽孢杆菌）浓度下表现出显著的生长抑制作用，与阳性对照相当。
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