Department of Nutrigenomics and Bromatology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
Int J Radiat Biol. 2019 Nov;95(11):1581-1587. doi: 10.1080/09553002.2019.1642543. Epub 2019 Jul 22.
The combined effect of exposure to a static magnetic field (SMF) and potentially toxic agents is a crucial research area, mainly due to occupational and environmental exposure to these factors. The aim of this study was to evaluate the effect of the simultaneous exposure of human fibroblasts to fluoride and a SMF. Control fibroblasts and fibroblasts that had been treated with fluoride were subjected to an SMF at a moderate induction (0.45, 0.55 and 0.65 T). The intracellular reactive oxygen species production, the concentration of malondialdehyde and the activities of superoxide dismutase and glutathione peroxidase were measured. Our investigations revealed that a moderate SMF does not enhance the action of fluoride in inducing oxidative stress by generating free radicals: A moderate SMF may be a factor that weakens the toxic action of fluoride, which is important for the health of individuals that are co-exposed to an SMF and fluoride ions (F) from occupational and environmental sources.
同时暴露于静磁场和潜在有毒剂的联合效应是一个重要的研究领域，主要是由于职业和环境暴露于这些因素。本研究旨在评估人成纤维细胞同时暴露于氟化物和静磁场的效果。对照成纤维细胞和经氟化物处理的成纤维细胞在中等诱导下（0.45、0.55 和 0.65 T）接受静磁场处理。测量细胞内活性氧的产生、丙二醛的浓度以及超氧化物歧化酶和谷胱甘肽过氧化物酶的活性。我们的研究表明，中等静磁场不会通过产生自由基增强氟化物诱导氧化应激的作用：中等静磁场可能是削弱氟化物毒性作用的一个因素，这对于同时暴露于静磁场和职业及环境来源的氟离子（F）的个体的健康很重要。
