The effect of simultaneous exposure of human fibroblasts to fluoride and moderate intensity static magnetic fields.

The combined effect of exposure to a static magnetic field (SMF) and potentially toxic agents is a crucial research area, mainly due to occupational and environmental exposure to these factors. The aim of this study was to evaluate the effect of the simultaneous exposure of human fibroblasts to fluoride and a SMF. Control fibroblasts and fibroblasts that had been treated with fluoride were subjected to an SMF at a moderate induction (0.45, 0.55 and 0.65 T). The intracellular reactive oxygen species production, the concentration of malondialdehyde and the activities of superoxide dismutase and glutathione peroxidase were measured. Our investigations revealed that a moderate SMF does not enhance the action of fluoride in inducing oxidative stress by generating free radicals: A moderate SMF may be a factor that weakens the toxic action of fluoride, which is important for the health of individuals that are co-exposed to an SMF and fluoride ions (F) from occupational and environmental sources.