University of California, Los Angeles, California.
University of Texas Health Science Center at Houston, Houston, Texas.
J Clin Endocrinol Metab. 2019 Oct 1;104(10):4857-4864. doi: 10.1210/jc.2018-02785.
Microscopic measurement of adipocyte size is the gold standard for determining adipose tissue (AT) quality. AT density on CT may also reflect adipocyte quality (lower density = poorer quality).
We used abdominal subcutaneous AT (SAT) specimens and CT scans to validate CT SAT density as a marker of SAT quality in adults living with HIV.
Secondary data analysis from completed trial of antiretroviral therapy (ART) initiation (ACTG A5224s). CT abdominal SAT density was measured in HU. SAT specimens were digitally scanned for calculation of mean adipocyte area.
Participants had SAT biopsy and CT data at baseline (n = 54) and HIV-1 RNA <50 copies per milliliter on ART and biopsy or CT data at week 96 (n = 30).
Spearman correlations and linear regression models adjusting for participant characteristics examined associations between SAT density and adipocyte area.
Baseline median age was 40 years, CD4+ T lymphocyte count 219 cells per cubic millimeter, and body mass index 26.0 kg/m2; 89% were male and 67% white. Median SAT area and density were 199 cm2 and -100 HU. Over 96 weeks, SAT area increased (+18%) and SAT density decreased (-3%). Mean SAT adipocyte area correlated with SAT density (P < 0.01) off and on ART after adjustment for SAT area, age, race, sex, CD4+ T lymphocyte count, and HIV-1 RNA.
CT SAT density correlates with biopsy-quantified SAT adipocyte size in adults with HIV on and off ART, suggesting that CT is a useful tool for noninvasive assessment of SAT quality.
脂肪组织（AT）质量的金标准是测量脂肪细胞的微观大小。CT 上的 AT 密度也可能反映脂肪细胞的质量（密度越低，质量越差）。
我们使用腹部皮下 AT（SAT）标本和 CT 扫描来验证 CT SAT 密度作为成人 HIV 感染者 SAT 质量的标志物。
完成的抗逆转录病毒治疗（ART）启动试验（ACTG A5224s）的二次数据分析。CT 腹部 SAT 密度以 HU 为单位进行测量。SAT 标本进行数字化扫描，计算平均脂肪细胞面积。
基线时（n = 54）有 SAT 活检和 CT 数据的参与者以及在 ART 和活检或 CT 数据上 HIV-1 RNA <50 拷贝/毫升的参与者（n = 30）。
基线时的中位年龄为 40 岁，CD4+T 淋巴细胞计数为 219 个细胞/立方毫米，体重指数为 26.0 kg/m2；89%为男性，67%为白人。SAT 面积和密度的中位数分别为 199 cm2和-100 HU。在 96 周期间，SAT 面积增加（+18%），SAT 密度降低（-3%）。在调整 SAT 面积、年龄、种族、性别、CD4+T 淋巴细胞计数和 HIV-1 RNA 后，SAT 脂肪细胞面积与 SAT 密度相关（P<0.01）。
CT SAT 密度与活检定量的 HIV 成人 ART 前后 SAT 脂肪细胞大小相关，表明 CT 是评估 SAT 质量的有用非侵入性工具。
