Brayton Cory F, Boyd Kelli L, Everitt Jeffrey L, Meyerholz David K, Treuting Piper M, Bolon Brad
Department of Molecular and Comparative Pathobiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
ILAR J. 2018 Dec 1;59(1):1-3. doi: 10.1093/ilar/ilz008.
This issue of ILAR Journal focusses on pathology and pathologists in biomedical research, more specifically in preclinical translational research involving (nonhuman) animals, emphasizing academic settings. Considerations in study design and planning to maximize benefit from pathologists and pathology resources are reviewed. Adjunctive technologies including molecular techniques, digital pathology, and imaging are highlighted. Additional considerations regarding safety and regulatory concerns, and veterinary clinical trials are reviewed as well. Pathology has been fundamental to understanding clinical disease, remains fundamental to diagnosing disease, and is required in drug and device development. Broader integration of pathology expertise and well-designed pathology investigations have much to offer research rigor and reproducibility, and successful translation from biomedical research.
本期《实验动物资源学报》聚焦于生物医学研究中的病理学及病理学家，更具体地说是涉及（非人类）动物的临床前转化研究，重点是学术环境。文中回顾了在研究设计和规划中如何充分利用病理学家和病理学资源以实现效益最大化的相关考量。文中还强调了包括分子技术、数字病理学和成像技术在内的辅助技术。此外，也回顾了有关安全和监管问题以及兽医临床试验的其他考量。病理学一直是理解临床疾病的基础，至今仍是疾病诊断的基础，并且在药物和器械研发中不可或缺。更广泛地整合病理学专业知识和精心设计的病理学研究，对于提高研究的严谨性、可重复性以及生物医学研究的成功转化具有重要意义。
