Wallace J M, Trundy R L
Vanderbilt University Medical Center in Nashville, Tennessee.
Biological and Animal Care Safety Section, Vanderbilt Environmental Health & Safety, Vanderbilt University Medical Center, Nashville, Tennessee.
ILAR J. 2018 Dec 1;59(1):111-118. doi: 10.1093/ilar/ily027.
Animal research pathology encompasses a wide array of procedures and may involve work with a variety of animal species and hazards. To protect laboratory personnel and ensure data integrity, pathologists must be familiar with the activities performed in their laboratories and the applicable regulatory and safety requirements. Failure to address issues proactively may result in exposure of personnel to hazardous materials and/or collection of data in a manner that does not conform to animal welfare or quality control standards. This manuscript provides a brief introduction to important animal research pathology regulatory and safety considerations. The importance of close communication between the principal investigator, pathologist, laboratory personnel, Institutional Animal Care and Use Committee, and institutional safety office/experts is emphasized and a mechanism for improving communication is discussed.
动物研究病理学涵盖了一系列广泛的程序，可能涉及与多种动物物种及危害因素打交道。为保护实验室人员并确保数据完整性，病理学家必须熟悉其实验室所开展的活动以及适用的法规和安全要求。未能积极解决问题可能会导致人员接触有害物质和/或以不符合动物福利或质量控制标准的方式收集数据。本手稿简要介绍了动物研究病理学重要的法规和安全注意事项。强调了首席研究员、病理学家、实验室人员、机构动物护理和使用委员会以及机构安全办公室/专家之间密切沟通的重要性，并讨论了改善沟通的机制。
