Port Matthias, Majewski Matthäus, Abend Michael
Bundeswehr Institute of Radiobiology, Munich, Germany.
Radiat Prot Dosimetry. 2019 Dec 31;186(1):126-129. doi: 10.1093/rpd/ncz058.
The relation of radiation exposure (dose) with acute radiation syndrome (ARS) depends on many factors. In this overview, we reconsider (1) radiation exposure characteristics (e.g. radiation quality, fractionation, dose rate, partial/total body irradiation) and (2) biological processes (e.g. radiosensitivity, cell cycle dependency, oxygenation) affecting acute health effects after exposure. Furthermore we include evidence from recently published work that examined the relationship of absorbed dose and risk of clinically relevant ARS in persons exposed after a radiation accident. We introduce the concept of radiation-related bioindicators for effect prediction. Bioindicators are considered here to be factors that integrate multiple radiation exposure characteristics and cell- and molecular-based processes to improve clinical prediction in persons with ARS.
辐射暴露（剂量）与急性放射综合征（ARS）之间的关系取决于许多因素。在本综述中，我们重新审视（1）辐射暴露特征（如辐射质量、分次照射、剂量率、局部/全身照射）以及（2）影响暴露后急性健康效应的生物学过程（如放射敏感性、细胞周期依赖性、氧合作用）。此外，我们纳入了最近发表的研究证据，这些研究探讨了辐射事故后受照人员吸收剂量与临床相关ARS风险之间的关系。我们引入了用于效应预测的辐射相关生物标志物的概念。在此，生物标志物被视为整合多种辐射暴露特征以及基于细胞和分子的过程以改善ARS患者临床预测的因素。
