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神经干细胞动力学:脑瘤的发生。

Neural stem cell dynamics: the development of brain tumours.

机构信息

The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

出版信息

Curr Opin Cell Biol. 2019 Oct;60:131-138. doi: 10.1016/j.ceb.2019.06.001. Epub 2019 Jul 19.

Abstract

Determining the premalignant lesions that develop into malignant tumours remains a daunting task. Brain tumours are frequently characterised by a block in differentiation, implying that normal developmental pathways become hijacked during tumourigenesis. However, the heterogeneity of stem cells and their progenitors in the brain suggests there are many potential routes to tumour initiation. Studies in Drosophila melanogaster have enhanced our understanding of the tumourigenic potential of distinct cell types in the brain. Here we review recent studies that have improved our knowledge of neural stem cell behaviour during development and in brain tumour models.

摘要

确定发展为恶性肿瘤的癌前病变仍然是一项艰巨的任务。脑瘤的特征通常是分化受阻,这意味着在肿瘤发生过程中正常的发育途径被劫持。然而,大脑中的干细胞及其祖细胞的异质性表明,肿瘤起始有许多潜在的途径。在黑腹果蝇中的研究增强了我们对大脑中不同类型细胞的肿瘤发生潜力的理解。在这里,我们回顾了最近的研究,这些研究提高了我们对神经干细胞在发育过程中和在脑肿瘤模型中的行为的认识。

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