School of Environmental Science and Engineering, Donghua University, Shanghai, 201620, China; MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, Zhejiang University, Hangzhou, 310058, China.
MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, Zhejiang University, Hangzhou, 310058, China.
J Hazard Mater. 2019 Dec 15;380:120867. doi: 10.1016/j.jhazmat.2019.120867. Epub 2019 Jul 11.
Transplacental exposure to per/polyfluoroalkyl substances (PFASs) may impact fetal growth, but published evidence are still sparse and not in agreement. Moreover, little is known on the occurrence of emerging chlorinated polyfluorinated ether sulfonates (Cl-PFESAs, 6:2 and 8:2) in maternal-neonatal population. This study investigated eleven PFASs by analyzing 98 cord samples from Hangzhou, China. All target compounds can be transported across placenta, with highest median concentrations of 4.07, 1.05 and 0.731 ng/mL for PFOS, PFOA, and 6:2 Cl-PFESA. Older ages and higher pre-pregnancy BMI were associated with higher cord PFASs concentration; being primiparous was also significantly associated. Notably, after adjusting for potential confounders, PFOS was negatively associated with birth weight (β = -417.3 g, 95% CI: -742.1, -92.4, p = 0.011, per a log unit increase in exposure) and ponderal index (β = -0.005 g/cm, 95% CI: -0.008, -0.002, p = 0.000). PFOS and PFHxS were also indicated to be associated with small for gestational age birth (SGA) (p < 0.05). Although no evidence of association was observed between Cl-PFESAs and birth outcomes in this study, the bioaccumulative properties and development toxicity of Cl-PFESAs deserve continuous concern.
胎盘暴露于全氟/多氟烷基物质（PFASs）可能会影响胎儿生长，但已发表的证据仍然很少且不一致。此外，母体-新生儿人群中新兴的氯化多氟醚磺酸（Cl-PFESAs，6:2 和 8:2）的发生情况知之甚少。本研究通过分析来自中国杭州的 98 份脐带样本，研究了 11 种 PFASs。所有目标化合物均可穿过胎盘转运，其中 PFOS、PFOA 和 6:2 Cl-PFESA 的中位数浓度最高，分别为 4.07、1.05 和 0.731ng/mL。年龄较大和较高的孕前 BMI 与脐带 PFASs 浓度较高有关；初产妇也与之显著相关。值得注意的是，在调整了潜在混杂因素后，PFOS 与出生体重呈负相关（β=-417.3g，95%CI：-742.1，-92.4，p=0.011，每增加一个对数单位暴露）和体重指数（β=-0.005g/cm，95%CI：-0.008，-0.002，p=0.000）。PFOS 和 PFHxS 也与小于胎龄儿（SGA）有关（p<0.05）。尽管本研究未观察到 Cl-PFESAs 与出生结局之间存在关联，但 Cl-PFESAs 的生物累积特性和发育毒性仍值得持续关注。
