Department of Neuroradiology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.
Department of Neuroradiology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.
J Neurol Sci. 2019 Sep 15;404:63-65. doi: 10.1016/j.jns.2019.07.004. Epub 2019 Jul 9.
We investigated the frequency and pattern of blood-brain barrier as well as blood-retina barrier impairment in transient global amnesia (TGA) as demonstrated by hyperintense acute reperfusion marker (HARM) and gadolinium leakage in ocular structures (GLOS) respectively on fluid attenuated inversion recovery images (FLAIR).
Patients with TGA who underwent repeated MRI after intravenous contrast agent administration were identified and the presence of GLOS in the anterior chamber and vitreous body and HARM noted on FLAIR.
Overall 10 patients (IQR 64.25-71.75 years; 4 (40%) patients were male) were included. On contrast-enhanced FLAIR, GLOS was observed in 3 (30%) patients; in all of these in the anterior chamber and vitreous body as well as bilateral and symmetrical. HARM was observed in none of the patients. Frequency of hippocampal DWI lesions, as well as extent of age related white matter lesions did not differ significantly between patients with and without GLOS.
In contrast to HARM, GLOS is a relatively common finding in TGA patients. As GLOS is thought to share its pathophysiology at least to some extent with HARM and is associated with HARM in ischemic stroke, it might be used as surrogate marker for blood-brain barrier impairment in TGA.
我们通过磁共振液体衰减反转恢复（FLAIR）成像上的急性再灌注高信号标记物（HARM）和眼部结构钆渗漏（GLOS），分别研究了短暂性全面遗忘症（TGA）中血脑屏障和血视网膜屏障损伤的频率和模式。
确定了经静脉造影剂给药后接受重复磁共振成像检查的 TGA 患者，并在 FLAIR 上观察到前房和玻璃体中的 GLOS 以及 HARM 的存在。
共纳入 10 例患者（IQR 64.25-71.75 岁；4 例患者为男性，占 40%）。在增强 FLAIR 上，3 例（30%）患者观察到 GLOS；所有患者均在前房和玻璃体中出现，双侧对称。所有患者均未观察到 HARM。有和无 GLOS 的患者之间，海马 DWI 病变的频率以及与年龄相关的白质病变的程度无显著差异。
与 HARM 相反，GLOS 是 TGA 患者中相对常见的发现。由于 GLOS 的病理生理学至少在一定程度上与 HARM 共享，并且与缺血性卒中中的 HARM 相关，因此它可能被用作 TGA 中血脑屏障损伤的替代标志物。
