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从 EOD-1 中提取的石房蛤毒素对饮食诱导肥胖小鼠代谢综合征相关参数的影响。

Effects of Paramylon Extracted from EOD-1 on Parameters Related to Metabolic Syndrome in Diet-Induced Obese Mice.

机构信息

Studies in Human Life Sciences, Graduate School of Studies in Human Culture, Otsuma Women's University, Chiyoda-ku, Tokyo 102-8357, Japan.

The Institute of Human Culture Studies, Otsuma Women's University Chiyoda-ku, Tokyo 102-8357, Japan.

出版信息

Nutrients. 2019 Jul 21;11(7):1674. doi: 10.3390/nu11071674.

DOI:10.3390/nu11071674
PMID:31330894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6682983/
Abstract

Paramylon (PM), a type of β-glucan, functions like dietary fiber, which has been suggested to exert a protective effect against obesity. We evaluated the potential beneficial effects of PM powder on obesity in mice. Male C57BL/6J mice were fed a high-fat diet supplemented with either 2.5 or 5% PM powder, extracted from , for 74 days. Growth parameters, abdominal fat content, serum biochemical markers, hepatic lipid accumulation and hepatic mRNA expression were measured. Dietary supplementation with PM resulted in decreased food efficiency ratios and abdominal fat accumulation. Dose-dependent decreases were observed in postprandial glucose levels, serum low-density lipoprotein (LDL)-cholesterol, and serum secretary immunoglobulin A (sIgA) concentrations. PM supplementation increased peroxisome proliferator-activated receptor α (PPARα) mRNA expression in the liver which is suggested to induce β-oxidation through activation of acyl-coenzyme A oxidase (ACOX), carnitine palmitoyltransferase (CPT) and fatty acid transport protein 2 (FATP2) mRNA expression. Changes in fatty acid metabolism may improve lipid and glucose metabolism. In conclusion, a preventive effect against obesity was observed in mice given a PM-enriched diet. The mechanism is suggested to involve a reduction in both serum LDL-cholesterol levels and the accumulation of abdominal fat, in addition to an improvement in postprandial glucose concentration.

摘要

海藻糖（PM）是一种β-葡聚糖，其功能类似于膳食纤维，据报道膳食纤维对肥胖具有保护作用。我们评估了 PM 粉末对肥胖小鼠的潜在有益作用。雄性 C57BL/6J 小鼠喂食高脂肪饮食，补充 2.5%或 5%的 PM 粉末，该 PM 粉末从 中提取，持续 74 天。测量生长参数、腹部脂肪含量、血清生化标志物、肝脂质积累和肝 mRNA 表达。PM 的饮食补充导致食物效率比和腹部脂肪积累降低。观察到餐后血糖水平、血清低密度脂蛋白（LDL）-胆固醇和血清分泌型免疫球蛋白 A（sIgA）浓度呈剂量依赖性降低。PM 补充增加了肝脏中过氧化物酶体增殖物激活受体 α（PPARα）mRNA 的表达，这被认为通过激活酰基辅酶 A 氧化酶（ACOX）、肉碱棕榈酰转移酶（CPT）和脂肪酸转运蛋白 2（FATP2）mRNA 的表达来诱导β-氧化。脂肪酸代谢的变化可能改善脂质和葡萄糖代谢。总之，给肥胖小鼠喂食富含 PM 的饮食可预防肥胖。其机制可能涉及降低血清 LDL-胆固醇水平和腹部脂肪积累，以及改善餐后血糖浓度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14d/6682983/ed48e1aa2be6/nutrients-11-01674-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14d/6682983/e08822e2b873/nutrients-11-01674-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14d/6682983/a4e5a6bb470f/nutrients-11-01674-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14d/6682983/ed48e1aa2be6/nutrients-11-01674-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14d/6682983/e08822e2b873/nutrients-11-01674-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14d/6682983/a4e5a6bb470f/nutrients-11-01674-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b14d/6682983/ed48e1aa2be6/nutrients-11-01674-g003.jpg

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本文引用的文献

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Nutrients. 2019 May 22;11(5):1144. doi: 10.3390/nu11051144.
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Anti-fibrotic activity of and paramylon in a mouse model of non-alcoholic steatohepatitis.小球藻多糖和副淀粉在非酒精性脂肪性肝炎小鼠模型中的抗纤维化活性。
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Simultaneous Intake of and Vegetables Exerts Synergistic Anti-Obesity and Anti-Inflammatory Effects by Modulating the Gut Microbiota in Diet-Induced Obese Mice.
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Effects of paramylon-rich EOD-1 powder on visceral fat obesity in moderately obese Japanese adults: A randomized, double-blind, placebo-controlled, parallel-group trial.富含副淀粉的EOD-1粉末对中度肥胖日本成年人内脏脂肪型肥胖的影响：一项随机、双盲、安慰剂对照、平行组试验。
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Paramylon from Prevents Lipopolysaccharide-Induced Acute Liver Injury.海藻糖可预防脂多糖诱导的急性肝损伤。
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同时摄入 和蔬菜可通过调节饮食诱导肥胖小鼠的肠道微生物群发挥协同的抗肥胖和抗炎作用。
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