口服绿藻小球藻可抑制自发性 2 型糖尿病模型 OLETF 大鼠的高血糖。

Oral administration of green algae, Euglena gracilis, inhibits hyperglycemia in OLETF rats, a model of spontaneous type 2 diabetes.

机构信息

Department of Dietary Environment Analysis, School of Human Science and Environment, University of Hyogo, 1-1-12 Sinzaike Honcho, Himeji 670-0092, Japan.

Department of Molecular Nutrition, School of Human Science and Environment, University of Hyogo, 1-1-12 Sinzaike Honcho, Himeji 670-0092, Japan.

出版信息

Food Funct. 2016 Nov 9;7(11):4655-4659. doi: 10.1039/c6fo00606j.

DOI:10.1039/c6fo00606j

PMID:27775129

Abstract

In the present study, the effects of Euglena and paramylon on hyperglycemia were examined in Otsuka Long-Evans Tokushima fatty (OLETF; type 2 diabetes mellitus model) rats. OLETF rats were fed an AIN-93 M diet containing cellulose, Euglena, or paramylon for 10 weeks. Long-Evans Tokushima Otsuka (LETO) rats were used as nondiabetic controls. An oral glucose-tolerance test (OGTT) was performed at 0 and 10 weeks. OLETF control rats were obese because of bulimia and showed abdominal fat accumulation and hyperglycemia. Euglena supplementation improved hyperglycemia and decreased food intake, body weight gain, and abdominal fat. However, there were no changes in the paramylon-supplemented group compared to the OLETF control group. Triglyceride concentrations in the serum and liver were lower in Euglena-supplemented rats than in OLETF control rats. There was a correlation between hepatic triglyceride concentration and the area under the curve (AUC) of OGTT at 10 weeks. This suggests that the improvement in glycemic control in the Euglena-supplemented group may depend on substances other than paramylon present in Euglena.

摘要

在本研究中，研究了眼虫和半乳聚糖对 Otsuka Long-Evans Tokushima 肥胖（OLETF；2 型糖尿病模型）大鼠高血糖的影响。OLETF 大鼠喂食含纤维素、眼虫或半乳聚糖的 AIN-93 M 饮食 10 周。Long-Evans Tokushima Otsuka（LETO）大鼠被用作非糖尿病对照。在 0 周和 10 周时进行口服葡萄糖耐量试验（OGTT）。由于暴食，OLETF 对照组大鼠肥胖，并表现出腹部脂肪堆积和高血糖。眼虫补充剂改善了高血糖，并减少了食物摄入、体重增加和腹部脂肪。然而，与 OLETF 对照组相比，半乳聚糖补充组没有变化。补充眼虫的大鼠血清和肝脏中的甘油三酯浓度低于 OLETF 对照组。在第 10 周时，肝甘油三酯浓度与 OGTT 的曲线下面积（AUC）之间存在相关性。这表明，眼虫补充组血糖控制的改善可能取决于眼虫中存在的除半乳聚糖以外的物质。