Bobokhojaev Oktam I, Osmanov Ali, Aliev Samariddin P, Radjabzoda Asliddin S, Avgonov Ziyovuddin T, Manonov Safarbek T, Denning David W
Department of Phthisiopneumology, Tajik State Medical University, 734003 Dushanbe, Tajikistan.
Global Action Fund for Fungal Infections, 1208 Geneva, Switzerland.
J Fungi (Basel). 2019 Jul 21;5(3):68. doi: 10.3390/jof5030068.
Tajikistan is a low-income country in Middle Asia with a population of 8.9 million people. Five percent of the population lives on less than 1.9 USD a day and 54% live on less than 5.5 USD a day. We have estimated the burden of serious fungal infections in Tajikistan. It was estimated that 168,834 Tajik women develop recurrent vulvovaginal candidiasis. Among HIV-positive patients, we estimate 490 patients with oesophageal candidiasis and 1260 patients with oral candidiasis, 41 cases of cryptococcal meningitis and 210 cases of pneumonia annually. According to our estimations there are 774 cases of chronic pulmonary aspergillosis (CPA) as a sequel of tuberculosis; CPA may occur as a consequence of multiple pulmonary conditions and the total prevalence of 4161 cases was estimated. We have estimated 6008 cased of allergic bronchopulmonary aspergillosis (ABPA) and 7930 cases of severe asthma with fungal sensitisation (SAFS), and 137 fungal asthma deaths annually. We have estimated 445 cases of candidemia a year applying a low European rate. There are approximately 283 cases of invasive aspergillosis annually. There are 189,662 (2.1% of the population) people suffering from serious fungal infections in Tajikistan. Hence, improving diagnostics is the first step of understanding a scale of the fungal burden.
塔吉克斯坦是中亚的一个低收入国家，人口为890万。5%的人口每天生活费不足1.9美元，54%的人口每天生活费不足5.5美元。我们估算了塔吉克斯坦严重真菌感染的负担。据估计，168,834名塔吉克女性患有复发性外阴阴道念珠菌病。在艾滋病毒呈阳性的患者中，我们估计每年有490例食管念珠菌病患者和1260例口腔念珠菌病患者，41例隐球菌性脑膜炎患者和210例肺炎患者。根据我们的估算，有774例慢性肺曲霉病（CPA）是结核病的后遗症；CPA可能由多种肺部疾病导致，估计总患病率为4161例。我们估算了6008例变应性支气管肺曲霉病（ABPA）和7930例真菌致敏重度哮喘（SAFS），以及每年137例真菌性哮喘死亡病例。我们采用较低的欧洲发病率估算每年有445例念珠菌血症病例。每年约有283例侵袭性曲霉病病例。塔吉克斯坦有189,662人（占人口的2.1%）患有严重真菌感染。因此，改进诊断是了解真菌负担规模的第一步。
