Shah Darshil, Nh Banka
Resident in Gastroenterology, Department of Gastroenterology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra.
Consultant in Gastroenterology, Department of Gastroenterology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra.
J Assoc Physicians India. 2018 Jun;66(6):103-104.
Hepatitis E virus is one of the leading causes of acute viral hepatitis in India but usually manifests as a mild self-limiting illness. It is known that severe intravascular hemolysis can occur in the course of acute Viral Hepatitis E in association with a G6PD deficiency state. Thalassemias are known to cause extravascular hemolysis. The role of β thalassemia trait in hemolysis during acute hepatitis E infection is not known. In this report we describe a rare coexistence of severe intravascular hemolysis in a patient with hepatitis E infection and β Thalassemia trait with bilirubin going upto 85 mg/dl without any renal dysfunction or complication. It may point towards an etiological basis of hemolysis in Hepatitis E due to Thalassemia.
戊型肝炎病毒是印度急性病毒性肝炎的主要病因之一，但通常表现为轻度自限性疾病。已知在急性戊型病毒性肝炎病程中，可发生严重血管内溶血，且与葡萄糖-6-磷酸脱氢酶（G6PD）缺乏状态有关。已知地中海贫血会导致血管外溶血。急性戊型肝炎感染期间，β地中海贫血特征在溶血中的作用尚不清楚。在本报告中，我们描述了1例戊型肝炎感染合并β地中海贫血特征的患者罕见地同时出现严重血管内溶血，胆红素高达85mg/dl，且无任何肾功能障碍或并发症。这可能提示地中海贫血导致戊型肝炎溶血的病因学基础。
