Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
Department of Endocrine and Metabolic Diseases, Rui Jin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Biomed Environ Sci. 2019 Jul;32(7):477-485. doi: 10.3967/bes2019.065.
The association between lipoprotein (a) [Lp(a)] levels and metabolic syndrome (MetS) remains uncertain, especially in the Asian population. The purpose of this study was to demonstrate the association between Lp(a) levels and MetS in a middle-aged and elderly Chinese cohort.
A cross-sectional study of 10,336 Chinese adults aged 40 years or older was conducted in Jiading District, Shanghai, China. Logistic regression analysis was used to evaluate the association between serum Lp(a) levels and MetS.
In the overall population, 37.5% of participants had MetS. Compared with individuals in the lowest quartile of serum Lp(a) levels, those in the highest quartile had a lower prevalence of MetS (30.9% vs. 46.9%, P for trend < 0.0001). Multivariate logistic regression analyses showed that compared with participants in the bottom quartile of serum Lp(a) levels, those in the top quartile had decreased odds ratio (OR) for prevalent MetS [multivariate-adjusted OR 0.45 (95% confidence interval 0.39-0.51); P < 0.0001]. Additionally, Lp(a) level was conversely associated with the risk of central obesity, high fasting glucose, high triglycerides, and low HDL cholesterol, but not with hypertension. Stratified analyses suggested that increasing levels of Lp(a) was associated with decreased risk of MetS in all the subgroups.
Serum Lp(a) level was inversely associated with the risk of prevalent MetS in a middle-aged and elderly Chinese cohort.
脂蛋白（a）[Lp(a)]水平与代谢综合征（MetS）之间的关联尚不确定，尤其是在亚洲人群中。本研究旨在证明中年和老年中国人群中 Lp(a)水平与 MetS 之间的关联。
在中国上海市嘉定区进行了一项横断面研究，纳入了 10336 名年龄在 40 岁及以上的中国成年人。采用 logistic 回归分析评估血清 Lp(a)水平与 MetS 之间的关系。
在总体人群中，37.5%的参与者患有 MetS。与血清 Lp(a)水平最低四分位的个体相比，血清 Lp(a)水平最高四分位的个体 MetS 的患病率较低（30.9%比 46.9%，趋势 P<0.0001）。多变量 logistic 回归分析显示，与血清 Lp(a)水平最低四分位的参与者相比，血清 Lp(a)水平最高四分位的参与者发生 MetS 的比值比（OR）降低[多变量校正 OR 0.45（95%置信区间 0.39-0.51）；P<0.0001]。此外，Lp(a)水平与中心性肥胖、空腹血糖升高、甘油三酯升高和高密度脂蛋白胆固醇降低的风险呈负相关，但与高血压无关。分层分析表明，随着 Lp(a)水平的升高，MetS 的风险降低，所有亚组均如此。
在中年和老年中国人群中，血清 Lp(a)水平与 MetS 的发病风险呈负相关。
