Department of Neurology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran.
Complement Ther Med. 2019 Aug;45:275-279. doi: 10.1016/j.ctim.2019.04.010. Epub 2019 Apr 23.
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. Several effector mechanisms are involved in the immunopathology of MS and a variety of medications such as beta interferons are applied to treat the disease. This study was conducted to evaluate the anti-inflammatory and immunomodulatory effects of sesame oil in combination with interferon beta-1a in MS treatment.
Ninety-three MS patients were enrolled in the study. The patients were randomly divided into two groups. The control group (n = 39) received 30 μg/week of interferon beta-1a intra-muscularly. The sesame oil-treated group (n = 54) received interferon beta-1a the same as the control group with the addition of 0.5 ml/kg/day of oral sesame oil for 6 months.
After the 6-month study period, the interleukin (IL)-10 concentration in the sesame oil-treated group was significantly greater than that of the control group (p = 0.04). The concentrations of interferon-γ (IFN-γ), nitric oxide (NO), and tumor necrosis factor-α (TNF-α) in the sesame oil group after treatment were significantly less than those of the control group (p = 0.029, p = 0.0001, and p = 0.01, respectively). Lymphocyte proliferation in the sesame oil-treated group was significantly lower at the end of the study than at the beginning (p = 0.001).
Sesame oil, through a decrease in IFN-γ secretion and anti-inflammatory and anti-oxidant activities, may have beneficial effects for MS patients.
多发性硬化症（MS）是一种中枢神经系统自身免疫性疾病。几种效应机制参与了 MS 的免疫病理学，多种药物如β干扰素被应用于治疗该疾病。本研究旨在评估芝麻油联合干扰素β-1a 在 MS 治疗中的抗炎和免疫调节作用。
93 名 MS 患者入组本研究。患者被随机分为两组。对照组（n=39）接受每周 30μg 干扰素β-1a 肌内注射。芝麻油治疗组（n=54）接受与对照组相同的干扰素β-1a 治疗，同时每日口服 0.5ml/kg 的芝麻油，疗程为 6 个月。
在 6 个月的研究期间，芝麻油治疗组的白细胞介素（IL）-10 浓度明显高于对照组（p=0.04）。治疗后芝麻油组的干扰素-γ（IFN-γ）、一氧化氮（NO）和肿瘤坏死因子-α（TNF-α）浓度明显低于对照组（p=0.029、p=0.0001 和 p=0.01）。芝麻油治疗组的淋巴细胞增殖在研究结束时明显低于开始时（p=0.001）。
芝麻油通过减少 IFN-γ 的分泌以及发挥抗炎和抗氧化作用，可能对 MS 患者有益。
