Gupta Aaryan, Roy Arpita, Roy Amit, Raja Vaseem, Sharma Kuldeep, Verma Rajan
Department of Biotechnology, Sharda School of Engineering & Technology, Sharda University, Greater Noida, India.
Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India.
Curr Pharm Biotechnol. 2025;26(5):665-679. doi: 10.2174/0113892010324850240923181408.
There is a rapid spread of Multiple Sclerosis disorder across the globe, around 2.8 million cases of Multiple Sclerosis in the world. Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by demyelination, neuroinflammation, and a wide spectrum of clinical manifestations. Many drugs have been tested on MS patients but there is no effective treatment for MS till now. So to inhibit the symptoms caused by MS we performed a study in which we identified various naturally occurring materials with neuroprotective effects on the body that can treat Multiple Sclerosis. The therapeutic strategies portion of the paper reviews the array of disease-modifying therapies currently available for MS management. This paper evaluated their mechanisms of action, efficacy, and safety profiles. It also addressed emerging treatment paradigms by using different naturally occurring materials, including personalized medicine approaches and novel therapies in development. This paper provides a comprehensive overview of the current state of knowledge regarding MS, focusing on its pathogenesis, diagnostic approaches, and therapeutic strategies.
全球多发性硬化症的发病率正在迅速上升，全球约有280万例多发性硬化症病例。多发性硬化症（MS）是一种中枢神经系统的慢性自身免疫性疾病，其特征是脱髓鞘、神经炎症和广泛的临床表现。许多药物已在MS患者身上进行了测试，但迄今为止尚无有效的MS治疗方法。因此，为了抑制MS引起的症状，我们开展了一项研究，在该研究中我们确定了各种对身体具有神经保护作用的天然物质，这些物质可以治疗多发性硬化症。本文的治疗策略部分回顾了目前可用于MS管理的一系列疾病修饰疗法。本文评估了它们的作用机制、疗效和安全性。它还探讨了使用不同天然物质的新兴治疗模式，包括个性化医疗方法和正在开发的新疗法。本文全面概述了目前关于MS的知识状况，重点关注其发病机制、诊断方法和治疗策略。
