T 细胞瘢痕在乳糜泻及其他疾病中的治疗和诊断意义。
Therapeutic and Diagnostic Implications of T Cell Scarring in Celiac Disease and Beyond.
机构信息
KG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Norway; Department of Immunology, University of Oslo, Oslo, Norway.
KG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Norway; Department of Immunology, University of Oslo, Oslo, Norway; Department of Immunology, Oslo University Hospital, Oslo, Norway.
出版信息
Trends Mol Med. 2019 Oct;25(10):836-852. doi: 10.1016/j.molmed.2019.05.009. Epub 2019 Jul 19.
Few therapeutic and diagnostic tools specifically aim at T cells in autoimmune disorders, but are T cells a narrow target in these diseases? Lessons may be learned from celiac disease (CeD), one of the few autoimmune disorders where the T cell driving antigens are known, i.e. dietary gluten proteins. T cell clonotypes specific to gluten are expanded, persist for decades and express a distinct phenotype in CeD patients. Cells with this phenotype are increased also in other autoimmune conditions. Accordingly, disease-specific CD4 T cells form an immunological scar in CeD and probably other autoimmune disorders. We discuss approaches how such T cells may be targeted for better treatment and diagnosis via their antigen specificity or via their expression of characteristic phenotypic markers.
在自身免疫性疾病中，很少有专门针对 T 细胞的治疗和诊断工具，但 T 细胞在这些疾病中是一个狭窄的靶点吗？从乳糜泻（CeD）中可以吸取一些经验，CeD 是少数几种已知驱动 T 细胞抗原的自身免疫性疾病之一，即膳食 gluten 蛋白。针对 gluten 的特定 T 细胞克隆型会扩张，持续数十年，并在 CeD 患者中表现出独特的表型。具有这种表型的细胞在其他自身免疫性疾病中也会增加。因此，在 CeD 中，以及可能在其他自身免疫性疾病中，疾病特异性 CD4 T 细胞形成了一种免疫性瘢痕。我们讨论了通过抗原特异性或通过其特征性表型标志物的表达来靶向这些 T 细胞以进行更好治疗和诊断的方法。
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