在多种自身免疫性疾病中鉴定出驱动乳糜泻的 CD4 T 细胞的独特表型。
Distinct phenotype of CD4 T cells driving celiac disease identified in multiple autoimmune conditions.
机构信息
KG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
出版信息
Nat Med. 2019 May;25(5):734-737. doi: 10.1038/s41591-019-0403-9. Epub 2019 Mar 25.
Abstract
Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4 T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4 T cells specific for disease-driving antigens in multiple autoimmune conditions.
摘要
通过将 HLA-DQ- 谷蛋白四聚体与质谱流式细胞术和 RNA 测序分析相结合，我们发现乳糜泻患者血液和肠道中的 gluten 特异性 CD4 T 细胞表现出一种令人惊讶的罕见表型。具有这种表型的细胞在硬皮病和系统性红斑狼疮患者中也升高，提示了一种在多种自身免疫性疾病中鉴定针对疾病驱动抗原的 CD4 T 细胞的方法。
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